Evidence map›Paper›PMID 41566725›Full record

ArticleMolecular nutrition & food research2026

The Effects of Biofortified Cowpeas on Iron, Glucose, and Lipid Metabolism in Rats Fed a High-Fat/High-Sugar Diet.

Ana Paula Ribeiro Gaspar, Cíntia Tomaz Sant' Ana, Mariana Grancieri, Ana Paula Carvalho de Moura Cruz, Leone Soromenho Viana, Eduardo Lorencetti Fornazier, Marisa da Silva Corrêa, Henrique Jordem Venial, Jankerle Neves Boeloni, Neuza Maria Brunoro Costa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana Paula Ribeiro GasparPostgraduate Program in Food Science and Technology, Agricultural Sciences and Engineering Center, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Cíntia Tomaz Sant' AnaPostgraduate Program in Food Science and Technology, Agricultural Sciences and Engineering Center, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Mariana GrancieriPostgraduate Program in Food Science and Technology, Agricultural Sciences and Engineering Center, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Ana Paula Carvalho de Moura CruzDepartment of Pharmacy and Nutrition, Center of Exact, Natural and Health Sciences, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Leone Soromenho VianaDepartment of Pharmacy and Nutrition, Center of Exact, Natural and Health Sciences, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Eduardo Lorencetti FornazierDepartment of Pharmacy and Nutrition, Center of Exact, Natural and Health Sciences, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Marisa da Silva CorrêaPostgraduate Program in Food Science and Technology, Agricultural Sciences and Engineering Center, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Henrique Jordem VenialDepartment of Veterinary Medicine, Agricultural Sciences and Engineering Center, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Jankerle Neves BoeloniDepartment of Veterinary Medicine, Agricultural Sciences and Engineering Center, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.
Neuza Maria Brunoro CostaPostgraduate Program in Food Science and Technology, Agricultural Sciences and Engineering Center, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa e Inovação do Espírito Santo
6 · The paper itself

Abstract

Iron deficiency anemia may affect carbohydrates and lipid metabolism. This study aimed to evaluate the iron bioavailability from biofortified cowpeas in the context of a high-fat/high-sugar diet and its relationship with carbohydrate and lipid metabolism. Forty-eight Wistar rats were induced to anemia for 21 days, and during the repletion phase (35 days), the animals received diets containing 12 ppm of iron from ferrous sulfate or biofortified (BRS Aracê and BRS Tumucumaque) and a conventional (BRS Pajeú) cowpeas. The biofortified cowpea Aracê showed a hemoglobin gain similar to ferrous sulfate, improved crypt size in the colon, lowered insulin levels and area under the curve in the glucose tolerance test compared to ferrous sulfate (p < 0.05). Hepcidin levels were similar between the groups. The biofortified cowpeas increased the production of short-chain fatty acids compared to ferrous sulfate (p < 0.05). Both biofortified and conventional cowpeas increased HDL-c concentrations, reduced the total cholesterol/HDL-c ratio, and decreased fecal triglyceride excretion (p < 0.05). The biofortification process favors beneficial metabolic changes in the iron, glucose, and lipid metabolism.

Indexed as

BiofortificationDiet, High-FatFabaceaeFood, FortifiedGlucoseIronLipid MetabolismAnemia, Iron-DeficiencyAnimalsBlood GlucoseDietary SugarsFatty Acids, VolatileFerrous CompoundsHepcidinsInsulinMaleBlood GlucoseDietary SugarsFatty Acids, VolatileFerrous Compoundsferrous sulfateGlucoseHepcidinsInsulinIronTriglyceridesbiofortificationcarbohydrate metabolismiron bioavailabilitylipid metabolism

Identifiers

PMID41566725
PMCPMC12824469

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.