Evidence map›Paper›PMID 41566790›Full record

ArticlePharmaceutical biology2026

Fermented

Ye Muhamad Aprizal, Mohd Izwan Mohamad Yusof, Norashirene Mohamad Jamil, Yuliadi Zamroni, Noor Syaffinaz Noor Mohamad Zin, Nur Saffa Aini Emran Yusli, Nur Fatin Farhana Zapri, Nurdiana Samsulrizal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Therapeutic Potential ofJournal of inflammation research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ye Muhamad AprizalTuAH Industrial Research Lab with Bio Fluid Sdn Bhd, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.
Mohd Izwan Mohamad YusofTuAH Industrial Research Lab with Bio Fluid Sdn Bhd, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.
Norashirene Mohamad JamilTuAH Industrial Research Lab with Bio Fluid Sdn Bhd, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.
Yuliadi ZamroniBiology Department, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, Indonesia.
Noor Syaffinaz Noor Mohamad ZinTuAH Industrial Research Lab with Bio Fluid Sdn Bhd, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.
Nur Saffa Aini Emran YusliTuAH Industrial Research Lab with Bio Fluid Sdn Bhd, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.
Nur Fatin Farhana ZapriTuAH Industrial Research Lab with Bio Fluid Sdn Bhd, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.
Nurdiana SamsulrizalTuAH Industrial Research Lab with Bio Fluid Sdn Bhd, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveThis study aimed to investigate the phytochemical composition, toxicity profile, and neuroprotective activity of fermented

methodsFMG was produced by fermentation with

resultsLC-MS analysis revealed a rich phytochemical profile. The no-observed-adverse-effect level (NOAEL) was 200 mg/kg/day, while the lowest-observed-adverse-effect level (LOAEL) was 600 mg/kg/day. Treatment at the 200 mg/kg dose significantly reversed memory deficits, restoring spontaneous alternation from 29.1% in scopolamine-treated rats to 82.6% ( DISCUSSION AND

conclusionsThe restorative effects of FMG are mediated by a dual mechanism involving the enhancement of central cholinergic and antioxidant systems. These results suggest that FMG possesses neuroprotective and antioxidant properties and could be a promising candidate for the management of cognitive deficits.

Indexed as

AntioxidantsCognitive DysfunctionDementiaMoringa oleiferaNeuroprotective AgentsPlant ExtractsReishiAcetylcholinesteraseAnimalsBrainDisease Models, AnimalFermentationHippocampusMaleMaze LearningOxidative StressAcetylcholinesteraseAntioxidantsNeuroprotective AgentsPlant ExtractsScopolamineBacillus subtilis-fermented mixtureplant-fungi formulationscopolamine-induced dementia ratsspatial learning and memorysubacute toxicity

Identifiers

PMID41566790
PMCPMC12829421

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.