Evidence map›Paper›PMID 41567201›Full record

ArticleFrontiers in immunology2025

Host-membrane lipid composition controls

Aswathi I Ramesh, Sumukha Hegde, Aarsh Mahendra Dabhi, Sriram Krishnamurthy, Divya Chandran, Shivakumar K Reddy, Prakash Peralam Yegneswaran, Kavitha Saravu, P V Mallikarjuna, Kavitha S Shettigar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aswathi I RameshCentre for Molecular Neurosciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Sumukha HegdeCentre for Molecular Neurosciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Aarsh Mahendra DabhiCentre for Molecular Neurosciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Sriram KrishnamurthySchrodinger India Private Limited, Hyderabad, India.
Divya ChandranCentre for Molecular Neurosciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Shivakumar K ReddyCentre for Molecular Neurosciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Prakash Peralam YegneswaranDepartment of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Kavitha SaravuDepartment of Infectious Diseases, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
P V MallikarjunaDepartment of Medical Laboratory Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Kavitha S ShettigarDepartment of Medical Laboratory Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Pritesh BhatSchrodinger India Private Limited, Bengaluru, India.
Varadaraj BhatDepartment of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
K R SabithaCentre for Molecular Neurosciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Indumathi MariappanCenter for Ocular Regeneration (CORE), Prof. Brien Holden Eye Research Center (BHERC), L.V. Prasad Eye Institute, Hyderabad, India.
Vishukumar AimaniandaDepartment of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Ashok K ShettyInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Naresh Vashisht College of Medicine, Texas A&M University Health Science Center, College Station, TX, United States.
Dinesh UpadhyaCentre for Molecular Neurosciences, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Results: GXM exposure induced subtle cell death, but progenitor cell proliferation was unaffected. Interestingly, GXM preferentially targeted neurons irrespective of the abundance of NSCs and astrocytes. Synaptophysin, an integral component of neuronal synaptic vesicles, was significantly reduced following GXM exposure. The untargeted lipidomics analysis revealed higher phosphatidylcholine levels and reduced phosphatidylethanolamine levels in human neurons compared to other cell types. The atomistic models revealed a significant attractive interaction energy between GXM and neuronal membranes, with phosphatidylcholine being primarily responsible. Conclusion: This study provides novel evidence that lipid membranes containing higher phosphatidylcholine are a primary target of GXM of

Indexed as

CryptococcosisCryptococcus neoformansHost-Pathogen InteractionsMembrane LipidsCell ProliferationCells, CulturedHumansInduced Pluripotent Stem CellsLipidomicsNeural Stem CellsNeuronsMembrane Lipidscerebral organoidsCryptococcus neoformanshuman neuronslipidomicsmembrane lipidsmeningoencephalitisneural stem cellspluripotent stem cells

Identifiers

PMID41567201
PMCPMC12815873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.