ReviewFrontiers in immunology2025
Exosomal crosstalk: the metastatic language of hepatocellular carcinoma.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Inflammation in hepatocellular carcinoma progression: a "Single Wick, dual interwoven strands" regulatory framework.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exosomes have garnered considerable attention in hepatocellular carcinoma (HCC) research owing to their critical function in regulating intercellular communication within the tumor microenvironment. Their inherent composition, structural integrity, and cargo-specific properties underpin critical functions in orchestrating cellular information transfer. This review delineates the fundamental biology of exosomes, their multifaceted pathophysiological roles in HCC, and the inherent translational promise of exosome-based therapeutic platforms for HCC management. Emerging evidence positions exosomes as dual-functional entities in HCC: not only propagating tumor progression and metastasis but also emerging as liquid biopsy-based diagnostic indicators for early detection and prognostic stratification, as well as nanoscale delivery platforms for site-specific therapeutic payloads. Nevertheless, despite growing recognition of exosomal functions in HCC, the precise mechanisms governing their functional duality and clinical translatability demand further elucidation. Through critical appraisal of extant literature, this review delineates actionable research priorities to catalyze mechanistic dissection and accelerate bench-to-bedside translation in exosome-based HCC management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.