Evidence map›Paper›PMID 41567262›Full record

ArticleOpen forum infectious diseases2026

Overcoming Ceftaroline Resistance in MRSA Using Ceftaroline-Carbapenem Combination Therapy.

Joshua Olson, Valliammai Alaguvel, Gabriel Pérez-Parra, Allen Jankeel, Anuj K Khetarpal, Valeria Rodríguez-Guevara, Vanessa Vu, George Sakoulas, Erlinda R Ulloa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. JAC-antimicrobial resistance · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joshua OlsonDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-1733-0431
Valliammai AlaguvelDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.
Gabriel Pérez-ParraDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0009-0006-6866-1106
Allen JankeelDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.
Anuj K KhetarpalDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0009-0009-7344-8440
Valeria Rodríguez-GuevaraDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0009-0003-0141-3085
Vanessa VuDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0009-0003-0657-2923
George SakoulasCollaborative to Halt Antibiotic-Resistant Microbes (CHARM), Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-6063-6217
Erlinda R UlloaDepartment of Pediatrics, University of California Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-0330-278X

Funding

Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
Beta-Lactamase Inhibitors Sensitize Multidrug-Resistant Gram-negative Pathogens to Innate Immune ClearanceK08AI151253 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ULLOA, ERLINDA ROSE · 2020 to 2024
$1.0M
NCATS NIH HHS UM1 TR004927NIAID NIH HHS K08 AI151253
6 · The paper itself

Abstract

The limited but rising threat of ceftaroline-resistant MRSA poses a therapeutic challenge. We show that ceftaroline plus carbapenems restores activity against a resistant strain both in vitro and in a murine bacteremia model. These findings support combination therapy as a potential strategy for difficult MRSA infections, warranting further clinical investigation.

Indexed as

bacteremiacarbapenemsceftarolineceftaroline-resistant MRSAcombination therapy

Identifiers

PMID41567262
PMCPMC12818010

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.