Evidence map›Paper›PMID 41567324›Full record

Trial reportFrontiers in nutrition2025

The effect of probiotic supplementation on perceived stress and bowel function in healthy young adults: evidence from a randomized controlled trial in Makkah.

Essra A Noorwali, Abeer M Aljaadi, Wafaa F Abusudah, Fatmah A Bakhdar, Dania H Bin-Ali, Amani Alshinawi, Asma Bawazir, Raghad A Mutlaq, Heba A Maimany, Layan A Barnawi and 3 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06464484 (The Effects Of Probiotics On Stress And Bowel Habits Among Healthy Adults From Umm Al-Qura University at Makkah), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06464484 nacompletednot on this map

The Effects Of Probiotics On Stress And Bowel Habits Among Healthy Adults From Umm Al-Qura University at Makkah: A Randomized Interventional Study

TypeinterventionalSponsorUmm Al-Qura UniversityRan2023 to 2024Enrolled85ConditionsStress, Constipation, Anthropometry, Bowel DiseaseArmsProbiotics (Lactobacillus rhamnosus GG (ATCC 53103)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Essra A NoorwaliClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Abeer M AljaadiClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Wafaa F AbusudahClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Fatmah A BakhdarPharmacology and Toxicology Department, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Dania H Bin-AliClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Amani AlshinawiClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Asma BawazirClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Raghad A MutlaqClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Heba A MaimanyClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Layan A BarnawiClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Bshayer MurshedClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Bayan AljaredClinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Firas S AzzehDepartment of Biology, Preparatory Year Program, Batterjee Medical College, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Young adults experience high, persistent stress due to academic, social, and financial pressures. Methods: In this randomized controlled trial, healthy adult participants with moderate-high Perceived Stress Scale (PSS) scores received Results: Sixty-six participants completed the trial (37 probiotic; 29 controls; mean age 21.97 ± 2.59 vs. 20.83 ± 1.91 years). Post-intervention, stress score reductions were significantly greater in the probiotic group than controls ( Conclusion: A 30-day Clinical trial registration: This trial is registered at ClinicalTrials.gov (Identifier: NCT06464484; https://clinicaltrials.gov/study/NCT06464484).

Indexed as

bowel functiongut–brain axisperceived stressprobioticsrandomized controlled trialSaudi Arabia

Identifiers

PMID41567324
PMCPMC12815857

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.