ArticleFrontiers in nutrition2025
Association of a novel nutritional marker, the triglyceride-cholesterol-body weight index, with 90-day unfavorable outcomes in acute ischemic stroke: a prospective cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Associations of cumulative exposure and dynamic trajectories of the triglyceride-total cholesterol-body weight index with new-onset cardiometabolic multimorbidity in middle-aged and older Chinese adults: evidence from a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Association of a novel nutritional index, the triglyceride-cholesterol-body weight index (TCBI), with incident mild cognitive impairment: CHARLS 2011-2018.Frontiers in nutrition · 2026Article
- Comparative associations of three nutritional indices with hematoma expansion after intracerebral hemorrhage.Frontiers in nutrition · 2026Article
- Baseline triglyceride-cholesterol-body weight index and risk of incident cardiovascular disease: evidence from the CHARLS and ELSA cohorts.Frontiers in nutrition · 2026Article
- A novel nutritional index for predicting stroke-heart syndrome and clinical outcomes after endovascular treatment.Frontiers in nutrition · 2026Article
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Abstract
Objective: Currently, research on the relationship between triglyceride-total cholesterol-body weight index (TCBI) and prognosis in patients with Acute Ischemic Stroke (AIS) is relatively limited. Therefore, this study aims to investigate the association between TCBI and the incidence of unfavorable functional outcomes in AIS patients. Methods: This secondary analysis included 1,764 AIS patients admitted to a South Korean hospital from January 2010 to December 2016. Binary logistic regression assessed the association between TCBI and 90-day unfavorable outcomes (defined as mRS score ≥3). A logistic regression model with restricted cubic spline functions was employed to explore the potential nonlinear relationship between them. A series of sensitivity analyses (including analyses restricted to participants without DM, without smoking, or with BMI < 28 kg/m Results: After adjusting for confounders, TCBI (per 100-unit increment) was inversely associated with 90-day unfavorable outcomes (OR = 0.972, 95% CI: 0.953-0.991). A nonlinear relationship was identified with an inflection point at TCBI = 1227.3. Below this inflection point, every 100-unit increment in TCBI demonstrated an OR of 0.928 (95% CI: 0.8866-0.9714) for unfavorable outcomes at 90 days. Above this turning point, the corresponding OR was 0.983 (95% CI: 0.955-1.287). Sensitivity analyses showed that the OR (95% CI) for the association between TCBI (per 100-unit) and 90-day unfavorable outcomes were 0.969 (0.944-0.993), 0.971 (0.946-0.996), and 0.972 (0.952-0.992) in participants without DM, without smoking, and with BMI < 28 kg/m Conclusion: This study revealed an independent negative link between TCBI and unfavorable outcomes at 90 days in patients with AIS. A nonlinear relationship between them was observed. When TCBI values were below 1227.3, a significant negative correlation was found. This provides new insights for prognostic stratification, optimization of rehabilitation strategies, and clinical management in AIS patients.
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