ArticleFrontiers in pediatrics2025
Diagnostic value of non-invasive indices for assessing liver fibrosis in Chinese children with metabolic dysfunction-associated steatotic liver disease.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction and objectives: The rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese children necessitates non-invasive fibrosis assessment. However, there is a paucity of pediatric-specific diagnostic tools. The objective of this study was to evaluate the performance of seven established non-invasive indices for staging liver fibrosis in Chinese children with biopsy-proven MASLD. Materials and methods: A cross-sectional analysis was conducted in children with MASLD. Liver fibrosis staging (F0-F4) was determined via histological assessment. The diagnostic performance of seven non-invasive indices (APRI, FIB-4, PNFI, TyG, AAR, API, NFS) was evaluated using Spearman correlation analysis and area under the receiver operating characteristic curve (AUROC) analysis. Results: A total of 110 children were included in the study, among whom significant fibrosis (F ≥ 2) was present in 36.3% (40/110), including 12.7% with F3 and 2.7% with cirrhosis (F4). When analyzing the correlations between indices and fibrosis stages, only modest positive correlations were observed for APRI (r = 0.32), FIB-4 (r = 0.23), PNFI (r = 0.24) and TyG (r = 0.24) (all Conclusion: The non-invasive fibrosis indices that have been validated demonstrated poor diagnostic accuracy and unreliable performance in Chinese children with MASLD. This diagnostic gap emphasizes the urgent need for the development of pediatric-specific diagnostic algorithms tailored for MASLD-related liver fibrosis.
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