Evidence map›Paper›PMID 41567505›Full record

ArticlebioRxiv : the preprint server for biology2026

DNA Polymerase α has pyrimidine dimer translesion activity that is suppressed during normal replication.

Projit Mukherjee, Abheerup Sarker, Grant D Schauer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Projit MukherjeeDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins CO 80523.
Abheerup SarkerDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins CO 80523.
Grant D SchauerDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins CO 80523.ORCID 0000-0002-6200-1311

Funding

Bypass Mechanisms in Eukaryotic ReplicationR35GM147105 · NIGMS · COLORADO STATE UNIVERSITY · PI Grant Schauer · 2022 to 2026
$1.9M
BYPASS MECHANISMS IN EUKARYOTIC REPLICATIONR00GM126143 · NIGMS · COLORADO STATE UNIVERSITY · PI SCHAUER, GRANT · 2019 to 2021
$747k
NIGMS NIH HHS R00 GM126143NIGMS NIH HHS R35 GM147105
6 · The paper itself

Abstract

To ensure rapid and accurate DNA replication during S-phase, the cell uses DNA damage tolerance (DDT) pathways, leaving lesions to be repaired after completion of replication. One established DDT pathway is Translesion Synthesis (TLS), in which lesions are bypassed by specialized TLS Polymerases that work in conjunction with the replisome. Here we demonstrate that DNA Polymerase alpha (Pol α), the replicative primase/polymerase, can also unexpectedly replicate through bulky lesions

Identifiers

PMID41567505
PMCPMC12817891

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.