Evidence map›Paper›PMID 41567632›Full record

ReviewFrontiers in pharmacology2025

Nobiletin promotes fracture healing by modulating macrophage polarization: a review.

Zhiqi Zhang, Shangyi Liu, Wenhao Li, Kangquan Shou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhiqi Zhang *Department of Burn, Three Gorges University Hospital of Traditional Chinese Medicine & Yichang Hospital of Traditional Chinese Medicine, Yichang, China.
Shangyi Liu *Department of Orthopedics, the First College of Clinical Medical Sciences, China Three Gorges University and Yichang Central People's Hospital, Yichang, China.
Wenhao LiDepartment of Orthopedics, the First College of Clinical Medical Sciences, China Three Gorges University and Yichang Central People's Hospital, Yichang, China.
Kangquan ShouDepartment of Orthopedics, the First College of Clinical Medical Sciences, China Three Gorges University and Yichang Central People's Hospital, Yichang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fracture healing is a complex process in which various cells, including macrophages, are involved. M1 macrophages and the cytokines they secrete exacerbate local inflammation and inhibit fracture healing, whereas M2 macrophages inhibit inflammation and promote tissue repair. An imbalance in the ratio of M1 to M2 macrophages leads to delayed healing and nonunion of the fracture. Nobiletin has received increasing attention in promoting fracture healing. Thus, the aim of this review article was to investigate the effects of nobiletin on macrophages during fracture healing, with a major focus on the potential mechanisms and applications, and to provide a reference for further research on this compound.

Indexed as

bone ununionfractureinflammatorymacrophage polarizationnobiletin

Identifiers

PMID41567632
PMCPMC12816298

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.