ArticleHawai'i journal of health & social welfare2025
Utilization of Genetic Testing and Surgical Implications in an Ethnically Diverse Hawaiian Population.
Article in Hawai'i journal of health & social welfare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Genetic testing is recommended for young women diagnosed with breast cancer. While studies have demonstrated an increased likelihood of variants of unknown significance (VUS) among racial/ethnic minorities compared to non-Hispanic Whites, results in the ethnically diverse population of Hawai'i are largely unknown. Additionally, current consensus guidelines dictate that VUS mutations are not clinically actionable and surgical decision-making is not standardized. This study aims to examine the utilization of genetic testing in Hawai'i and evaluate for any subsequent impacts on surgical practice patterns. A retrospective chart review of women age <45 diagnosed with breast cancer between 2016 and 2020 was performed at a single institution in Honolulu, Hawai'i. Ethnicity, cancer history, detected genes/variants, and surgical intervention were extracted. Of 236 patients identified, 134 (56.7%) were Asian, 57 (24.1%) Native Hawaiian/Pacific Islander (NHPI), and 45 (19.1%) Other. The majority (n=201, 85.2%) underwent genetic testing. A family history of breast cancer was predictive of testing (
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