ArticleFrontiers in medicine2025
Diagnostic value and prognostic significance of microRNA-210, serum creatinine, neutrophil gelatinase-associated lipocalin, blood urea nitrogen, cystatin C, and sequential organ failure assessment scores in patients with sepsis-associated acute kidney injury.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- A Simple Admission-Based Score for Early Mortality Risk Stratification in Non-Shock Sepsis: A Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Nomogram analysis of factors associated with prognosis in patients with sepsis-associated acute kidney injury: a case-control study based on LASSO regression.Frontiers in medicine · 2026Article
- Development and internal validation of a prediction model for early identification of sepsis-associated acute kidney injury based on admission serum biomarkers: a retrospective cohort study.Frontiers in medicine · 2026Article
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5 authors.
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Abstract
Background: Sepsis-associated acute kidney injury is common in critically ill patients and is strongly associated with adverse outcomes. Objective: To explore the diagnostic value and prognostic significance of microRNA (miRNA) miR-210, serum creatinine (Scr), neutrophil gelatinase-associated lipocalin (NGAL), blood urea nitrogen (BUN), cystatin C (CysC), and sequential organ failure assessment (SOFA) scores in patients with sepsis-associated acute kidney injury. Design: This was a retrospective study. Setting: This study was performed in the Department of Intensive Care Unit at Shengli Oilfield Central Hospital. Participants: A total of 81 sepsis patients treated at our hospital from April to November 2021 were chosen and divided into two groups according to whether acute kidney injury was present. Interventions: The levels of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores were detected, and an ROC curve was implemented to assess the diagnostic value. The risk factors influencing prognosis were assessed by binary logistic regression. Primary outcome measures: (1) Levels of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores; (2) Diagnostic value of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores; (3) Risk factors influencing the prognosis of patients with sepsis-associated acute kidney injury. Results: Compared with sepsis patients, levels of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores in patients with sepsis-associated acute kidney injury were elevated ( Conclusion: Our study demonstrated that miR-210, Scr, NGAL, BUN, CysC, and SOFA scores had significant diagnostic value in patients with sepsis-associated acute kidney injury and that miR-210 and SOFA scores had good prognostic value.
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