ArticleAmerican journal of clinical and experimental immunology2025
Analysis of the expression of ARNTL2 and miR-204-5p and their correlation with clinical pathological features in NSCLC patients.
Article in American journal of clinical and experimental immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo analyze the expression of Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2) and miR-204-5p in non-small cell lung cancer (NSCLC) patients and their correlation with clinicopathological characteristics.
methodsRespiratory department cases from April 2020 to April 2022 were selected, and patients were divided into an NSCLC group (80 cases) and a non-NSCLC group (60 cases). The expression levels of ARNTL2 and miR-204-5p and the survival status were compared between the two groups. The predictive value of ARNTL2 and miR-204-5p for mortality in NSCLC patients was analyzed.
resultsTCGA data showed ARNTL2 expression was significantly higher and hsa-miR-204-5p significantly lower in cancer versus normal tissues (P<0.05). Patients with high ARNTL2 or miR-204-5p expression had shorter survival than those with low expression (P<0.05). In NSCLC patients, ARNTL2 was elevated and miR-204-5p reduced compared to non-NSCLC (P<0.05). High ARNTL2 or low miR-204-5p expression correlated with older age, larger tumor size, higher malignancy, lymph node metastasis, advanced stage, and smoking history (P<0.05). Over 36 months, survival was lower with high ARNTL2 but higher with high miR-204-5p (P<0.05). Pearson analysis showed ARNTL2 positively and miR-204-5p negatively correlated with mortality (P<0.05). ROC analysis yielded AUCs, sensitivities, and specificities of 0.914/86.7%/86.2% for ARNTL2, 0.934/81.7%/96.2% for miR-204-5p, and 0.920/89.8%/97.7% for combined detection.
conclusionThe expression levels of ARNTL2 and miR-204-5p in NSCLC are closely associated with patient age, tumor differentiation, and lymph node metastasis, and they have high predictive value for NSCLC-related mortality.
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