Evidence mapPaperPMID 41567739Full record

ArticleAJO international2025

Development of a deep learning model to classify choroidal melanoma risk factors based on color fundus photographs.

Huzaifa Suri, P Connor Lentz, David A Leske, Mostafa Mousavi, Haley S D'Souza, Muhammad B Qureshi, Raymond Iezzi, Yogatheesan Varatharajah, Lauren A Dalvin

Abstract read
In one paragraph

Article in AJO international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huzaifa SuriDepartment of Electrical and Computer Engineering, University of Illinois, Urbana, IL, USA.ORCID 0009-0003-4571-666X
P Connor LentzMayo Clinic Alix School of Medicine, Rochester, MN, USA.ORCID 0009-0006-5642-9801
David A LeskeDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3048-8177
Mostafa MousaviDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Haley S D'SouzaDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-0938-1650
Muhammad B QureshiMayo Clinic Alix School of Medicine, Rochester, MN, USA.
Raymond IezziDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5126-1898
Yogatheesan VaratharajahDepartment of Computer Science & Engineering, University of Minnesota, Minneapolis, MN, USA.
Lauren A DalvinDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9710-4284

Funding

Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
NCATS NIH HHS KL2 TR002379
6 · The paper itself

Abstract

Choroidal melanoma is the most common malignant primary intraocular tumor and can develop either de novo or from a preexisting choroidal nevus, a benign pigmented lesion. Key risk factors for the transformation of choroidal nevus into melanoma include tumor diameter > 5 mm, tumor thickness > 2 mm, orange pigment, subretinal fluid, and low internal reflectivity on ultrasound. However, the assessment of many of these risk factors requires multimodal imaging equipment and skilled subspecialists, only available at tertiary referral centers. In this study, we developed and validated a deep learning approach to identifying these risk factors based solely on fundus images of choroidal nevi. Results indicate acceptable to excellent predictive performance for detection of all five risk factors. These findings suggest that deep learning models may be valuable tools for identifying high-risk choroidal nevi, particularly in resource-limited settings.

Indexed as

Artificial intelligenceChoroidal melanomaChoroidal nevusDeep learning modelOcular oncology

Identifiers

PMID41567739
PMCPMC12818915

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.