ArticleFrontiers in endocrinology2025
Serum uric acid as a diagnostic biomarker for preeclampsia: comparison with renal indices and cerebroplacental ratio.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the diagnostic performance of renal function-related indices (blood urea nitrogen (BUN), serum creatinine (sCr), serum uric acid (sUA), serum cystatin C (sCys C)) and the cerebroplacental ratio (CPR) for preeclampsia (PE). Methods: In a retrospective case-control design, we reviewed the medical records of 172 pregnant women (84 with PE and 88 normotensive controls) who delivered between 2021 and 2024. Independent risk factors were identified using logistic regression, and the Receiver Operating Characteristic (ROC) curve analysis was used to assess the discriminative ability of each parameter for detecting PE. Results: Compared with healthy controls, women with PE exhibited elevated sUA concentrations, greater pre-pregnancy body mass index (BMI), and lower CPR values (all Conclusion: Among the multiple renal function indices studied, sUA demonstrates the best diagnostic performance for PE and could serve as an effective biomarker for the clinical assessment of PE risk.
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