Evidence map›Paper›PMID 41567820›Full record

ArticleJID innovations : skin science from molecules to population health2026

Spatially controlled induction and regression of basal cell carcinoma, visualized by serial imaging in young and old mice.

Elisabeth A Pedersen, Marina Grachtchouk, Paul W Harms, Allison K C Furgal, Dawn Wilbert, Allesandra Hoover, Daryna V Hodgson, Katelyn Fiehler, Anissa Alam, Nihal Lingam and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisabeth A PedersenDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Marina GrachtchoukDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Paul W HarmsDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Allison K C FurgalRogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Dawn WilbertDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Allesandra HooverDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Daryna V HodgsonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Katelyn FiehlerDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Anissa AlamDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Nihal LingamDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Sunny Y WongDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Monique E VerhaegenDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Andrzej A DlugoszDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
TRAINING PROGRAM IN CELL AND MOLECULAR DERMATOLOGYT32AR007197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES TILFORD ELDER, Sunny Y Wong · 1986 to 2026
$4.2M
NCI NIH HHS P30 CA046592NIAMS NIH HHS P30 AR075043NIAMS NIH HHS T32 AR007197
6 · The paper itself

Abstract

Basal cell carcinoma (BCC) is the most common skin malignancy, and the risk of developing BCC increases with age. BCC results from dysregulated Hedgehog signaling leading to activation of GLI transcription factors. In this study, we examined the impact of aging on BCC in cohorts of young (n = 37) versus aged (n = 97) mice using a transgenic mouse model in which GLI2A (GLI2 activator) was induced in mice at either the age of 7 weeks or 22-24 months, and BCC tumor development was monitored by weekly imaging. Young mice developed tumors slightly sooner and in greater numbers than aged mice but demonstrated similar growth rates once tumors appeared. However, BCC-associated increases in blood vessel diameter, tortuosity, and ulceration were impacted by age. BCCs in both young and aged mice underwent similarly rapid regression after GLI2A transgene inactivation. Taken together, our findings reveal that aging affects tumor-associated vasculature but not BCC formation or regression in our model. These results are in keeping with the notion that a major contributor to the increased incidence of BCCs in elderly patients is the accumulation of oncogenic driver mutations over time rather than intrinsic changes in aged skin that promote BCC tumorigenesis.

Indexed as

AgingBasal cell carcinomaImagingMouse models

Identifiers

PMID41567820
PMCPMC12818135

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.