Evidence map›Paper›PMID 41567882›Full record

ArticleEngineering (Beijing, China)2024

Progress in Organ Bioprinting for Regenerative Medicine.

Xiang Wang, Di Zhang, Yogendra Pratap Singh, Miji Yeo, Guotao Deng, Jiaqi Lai, Fei Chen, Ibrahim T Ozbolat, Yin Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Engineering (Beijing, China), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang WangCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Di ZhangCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Yogendra Pratap SinghThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Miji YeoThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Guotao DengCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Jiaqi LaiCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Fei ChenCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Ibrahim T OzbolatThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Yin YuCenter for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Funding

Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Anna Karolina Palucka · 2019 to 2026
$23.1M
Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstructionR01DE028614 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI OZBOLAT, IBRAHIM · 2020 to 2024
$2.8M
High-throughput Spheroid Bioprinting Technology for Scalable Fabrication of TissuesR01EB034566 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ibrahim Ozbolat · 2023 to 2026
$2.2M
NIAID NIH HHS U19 AI142733NIBIB NIH HHS R01 EB034566NIDCR NIH HHS R01 DE028614
6 · The paper itself

Abstract

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body's limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

Indexed as

Organ printingRegenerative medicineThree-dimensional bioprintingTissue engineering

Identifiers

PMID41567882
PMCPMC12818943

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.