Evidence map›Paper›PMID 41568002›Full record

ArticleFrontiers in cellular and infection microbiology2025

Olanzapine affects bone formation via oral

Hui Yuan, Min-Yuan Wang, Rui-Xi Liu, Senjeet Sreekissoon, Qiong Liu, Li Tan, Ya-Qiong Zhao, Meng-Mei Zhong, Qian Zhang, Xiao-Lin Su and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Hui Yuan *Department of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Min-Yuan Wang *Department of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Rui-Xi LiuDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Senjeet SreekissoonDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qiong LiuDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li TanDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ya-Qiong ZhaoDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Meng-Mei ZhongDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qian ZhangDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiao-Lin SuDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ning-Xin ChenDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mei WangDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi-Fan YangDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jian-Nan LiDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
He-Qiong ZhengDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jin-Dong ChenDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yun-Zhi FengDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Feng-Yi ZhangDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yue GuoDepartment of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Olanzapine is a commonly used drug in the treatment of schizophrenia, but the mechanism of abnormal bone metabolism caused by olanzapine is still unclear. The change of microflora may be an important factor leading to the change of bone metabolism. Therefore, the purpose of this study was to explore a plausible hypothesis that olanzapine may aggravate abnormal bone metabolism and cause bacterial imbalance in patients with schizophrenia. Methods: This study intervened in mice by gavage with olanzapine to detect changes in alveolar bone tissue and oral microbiota. The effect of related bacteria on osteogenesis was further examined. Results: The results showed that Conclusions: Olanzapine may increase the relative abundance of oral

Indexed as

EnterococcusExtracellular MatrixOlanzapineOsteogenesisSerum Amyloid A ProteinAnimalsCollagen Type ICollagen Type I, alpha 1 ChainFemaleHumansLipopolysaccharidesMaleMiceMouthMulticenter Studies as TopicObservational Studies as TopicCollagen Type ICollagen Type I, alpha 1 ChainLipopolysaccharideslipoteichoic acidOlanzapineSerum Amyloid A ProteinTeichoic Acidsbone formationextracellular matrixolanzapineoral Enterococcusserum amyloid A1 gene

Identifiers

PMID41568002
PMCPMC12815755

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.