Evidence map›Paper›PMID 41568021›Full record

ArticleJHLT open2026

The right kind of rarefaction: Coronary microvascular remodeling in right ventricle failure.

Cyrus Vahdatpour, Katharine Clapham, Steven M Kawut, Kirk Jones, John J Ryan, Danielle Petty, Shannon Talbot, Kimberly Dumoff, Ellen C Keeley, Priti Lal and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Cyrus VahdatpourDivision of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX.
Katharine ClaphamDivision of Cardiovascular Medicine, University of Utah, Salt Lake City, UT.
Steven M KawutDivision of Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Kirk JonesDivision of Pulmonary and Critical Care Medicine, University of Florida, Gainesville, FL.
John J RyanDivision of Cardiovascular Medicine, University of Utah, Salt Lake City, UT.
Danielle PettyDivision of Pathology, University of Florida, Gainesville, FL.
Shannon TalbotDivision of Cardiovascular Medicine, University of Utah, Salt Lake City, UT.
Kimberly DumoffDivision of Pathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Ellen C KeeleyDivision of Cardiology, University of Florida, Gainesville, FL.
Priti LalDivision of Pathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Andrew J BryantDivision of Pulmonary and Critical Care Medicine, University of Florida, Gainesville, FL.
Alex M ParkerDivision of Cardiology, University of Florida, Gainesville, FL.
Jeremy A MazurekDivision of Cardiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Leonid MirsonDivision of Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Andrew MurphyDivision of Medicine, Pennsylvania Hospital, Philadelphia, PA.
Andrew BairdDivision of Cardiovascular Medicine, University of Utah, Salt Lake City, UT.
Megan SchwietertDivision of Pathology, University of Florida, Gainesville, FL.
Alissa SchurrDivision of Pathology, Thomas Jefferson University, Philadelphia, PA.
Andrew SteinDivision of Cardiology, University of Alabama, Birmingham, AL.
Scott M HansenCollege of Life Sciences, Bringham Young University, Provo, UT.
Zhining OuDivision of Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT.
Angela P PressonDivision of Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT.
Dylan MillerDivision of Pathology, University of Utah, Salt Lake City, UT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Right ventricular failure (RVF) is the primary determinant of outcomes in pulmonary hypertension (PH). Coronary microvascular dysfunction (CMD), defined by capillary rarefaction and endothelial dysfunction, may contribute to RVF but remains poorly characterized. CMD, defined by capillary rarefaction and endothelial dysfunction, may contribute to RVF through impaired myocardial oxygen delivery and fibrotic remodeling. Objectives: To characterize right ventricle (RV) CMD and myocardial fibrosis in explanted human hearts and examine associations with echocardiographic and hemodynamic indices of RVF across PH subtypes. Methods: We retrospectively analyzed 57 adult patients who underwent orthotopic heart transplantation at 3 institutions (2023-2024). Explanted hearts were classified by PH subtype: combined pre-/post-capillary PH (CpcPH, Results: A total of 57 hearts (70% male, median age 52 years) were analyzed. Median time from listing to transplantation was 1.6 months (IQR: 0.7-6.1). Mean RV capillary density was 653 ± 204 microvessels/mm Conclusions: Capillary rarefaction is a measurable histopathologic feature in explanted RV tissue that correlates with functional indices of RV performance. Our proof-of-concept findings suggest CMD may contribute to RV systolic dysfunction independent of PH subtype.

Indexed as

Capillary rarefactionCoronary microvascular dysfunctionDigital pathologyHeart transplantationPulmonary hypertensionRight ventricular failure

Identifiers

PMID41568021
PMCPMC12816859

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.