Evidence map›Paper›PMID 41568198›Full record

ArticleIBRO neuroscience reports2026

Norepinephrine and dopamine Imbalance in the medial frontal gyrus from patients with Alzheimer's disease.

Zuleyha Nihan Yurtsever, Silvia Capuani, Michela Fratini, Charles Nicaise, Yasmine Salman, Bernard Hanseeuw, Giovanni Augusto Carlesimo, Emanuele Claudio Latagliata, Roberto Coccurello

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In one paragraph

Article in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zuleyha Nihan YurtseverDepartment of Experimental Neurosciences, IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano, 64, Rome 00143, Italy.
Silvia CapuaniNational Research Council (CNR), Institute for Complex System (ISC), Via dei Taurini, 19, Rome 00185, Italy.
Michela FratiniSanta Lucia Foundation, IRCCS, Via Ardeatina 309, Rome 00179, Italy.
Charles NicaiseURPhyM, NARILIS, Université de Namur, Namur, Belgium.
Yasmine SalmanInstitute of Neuroscience, UCLouvain, Brussels, Belgium.
Bernard HanseeuwInstitute of Neuroscience, UCLouvain, Brussels, Belgium.
Giovanni Augusto CarlesimoLaboratory of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina, 354, Rome 00179, Italy.
Emanuele Claudio LatagliataDepartment of Experimental Neurosciences, IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano, 64, Rome 00143, Italy.
Roberto CoccurelloDepartment of Experimental Neurosciences, IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano, 64, Rome 00143, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate catecholaminergic alterations in the medial frontal gyrus (MFG) in Alzheimer's disease (AD) patients, including a case with TDP-43 pathology, with a focus on norepinephrine (NE) and dopamine (DA) signaling. Methods: Postmortem MFG tissue from five human donors, one with AD, one with AD and TDP-43 co-pathology (AD-TDP43), one preclinical AD, and two controls, was analyzed using high-performance liquid chromatography. Concentrations of NE, DA, and their primary metabolites (MHPG, DOPAC, HVA) were measured to assess neurotransmitter levels and turnover ratios. Results: Elevated MHPG levels were observed only in AD and AD-TDP43 patients, despite unchanged NE concentrations, indicating increased NE turnover. DA levels were also selectively elevated in AD and AD-TDP43 brains only. Possible impaired DA metabolism appeared consistent with reduced DOPAC/DA and HVA/DA ratios and DA turnover. Conclusions: Catecholaminergic dysfunction, marked by increased NE turnover and elevated DA levels, characterizes both AD and AD-TDP43 pathology in the MFG, implicating catecholamine imbalance in disease mechanisms. Significance: By revealing a selective increase in NE turnover and DA levels in the medial frontal lobe, these data may help to clarify the neurochemical imbalance linking cortical to subcortical neurodegeneration, such as that of the locus coeruleus and ventral tegmental area, to catecholamine innervation of the frontal cortex.

Indexed as

Alzheimer’s diseaseCatecholamineCognitive flexibilityDopamineExecutive functionsMedial frontal gyrusMHPGNeuropsychiatric symptomsNorepinephrinePatientsTDP-43

Identifiers

PMID41568198
PMCPMC12816894

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.