Evidence map›Paper›PMID 41568218›Full record

ArticleRSC advances2026

New multitarget antidiabetic potential agents based on sulfaguanidine: design, synthesis, and biological evaluation.

Mohammed Salah Ayoup, Asmaa E Kassab, Amr Sonousi, Shaimaa E Eldaly, Jawaher Y Al Nawah, Hamida Abdel-Hamid, Doaa A Ghareeb, Samah Ashraf, Manar Ahmed Fouad

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed Salah AyoupDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia mayoup@kfu.edu.sa.
Asmaa E KassabDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street, P.O. Box 11562 Cairo Egypt.ORCID https://orcid.org/0000-0002-6091-829X
Amr SonousiDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University Kasr El-Aini Street, P.O. Box 11562 Cairo Egypt.ORCID https://orcid.org/0000-0002-7111-8837
Shaimaa E EldalyDepartment of Chemistry, Faculty of Science, Alexandria University P.O. Box 426 Alexandria 21321 Egypt manar.ahmed@alexu.edu.eg.ORCID https://orcid.org/0009-0006-3587-7576
Jawaher Y Al NawahDepartment of Chemistry, College of Science, King Faisal University Al-Ahsa 31982 Saudi Arabia mayoup@kfu.edu.sa.ORCID https://orcid.org/0009-0002-8617-9445
Hamida Abdel-HamidDepartment of Chemistry, Faculty of Science, Alexandria University P.O. Box 426 Alexandria 21321 Egypt manar.ahmed@alexu.edu.eg.
Doaa A GhareebBio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University Alexandria Egypt.ORCID https://orcid.org/0000-0003-3327-4377
Samah AshrafBio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University Alexandria Egypt.ORCID https://orcid.org/0000-0001-5302-2092
Manar Ahmed FouadDepartment of Chemistry, Faculty of Science, Alexandria University P.O. Box 426 Alexandria 21321 Egypt manar.ahmed@alexu.edu.eg.ORCID https://orcid.org/0000-0001-9128-9118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes-related morbidity and mortality rates are high, making type 2 diabetes (T2DM) a serious issue at an alarming rate. This work focused on the design and synthesis of a series of new sulfaguanidine derivatives connected through a hydrazine linker to five-membered heterocycles. All synthesized derivatives were screened for

Identifiers

PMID41568218
PMCPMC12817124

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.