ReviewFrontiers in aging2025
Dietary polyphenols and sarcopenia: epigenetic mechanisms and geroscience perspectives for muscle health in aging.
Review in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Morphological Characterization, Interaction Mechanisms, and Functional Properties of a Non-Covalent Whey Protein Isolate-Ellagic Acid Complex.Foods (Basel, Switzerland) · 2026Article
- Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.Nutrients · 2026Review
- Phytochemical-Based Therapeutic Strategies for Sarcopenia: From Molecular Mechanisms to Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2026Review
- The Role of Polyphenols in Regulating Skeletal Muscle Development and Homeostasis: Molecular Mechanisms and Potential Medical Applications.Molecular nutrition & food research · 2026Review
- Targeting TGF-β-driven fibrotic, epigenetic remodeling and Bax/Bcl-2 through polyphenol-exercise synergy: molecular implications for biomechanical impairment and rehabilitation in cancer.Frontiers in oncology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review explores the effects of dietary polyphenols, such as resveratrol, quercetin, epigallocatechin gallate, and curcumin, on sarcopenia, with a particular focus on the underlying molecular and epigenetic mechanisms. These bioactive compounds may modulate key signaling pathways, including mTOR, NF-κB, and AMPK, while also influencing epigenetic processes such as DNA methylation, histone modifications, and microRNA regulation. Through these actions, polyphenols may reduce oxidative stress and chronic low-grade inflammation (inflammaging), enhance mitochondrial function, and contribute to the preservation of muscle mass and strength in older adults. Evidence from experimental and clinical studies investigating the impact of polyphenols on muscle health and their potential in the prevention or attenuation of sarcopenia will be discussed. In addition, current challenges and future perspectives will be addressed, emphasizing the role of epigenetic biomarkers and the potential synergy with physical exercise as part of integrated geroscience strategies to optimize muscle health during aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.