Evidence map›Paper›PMID 41568342›Full record

ArticleACS medicinal chemistry letters2026

Monica Rosas-Lemus, Sudhakar Athe, George Minasov, Jason A Pattie, Joseph S Brunzelle, Irene Chau, Fengling Li, Masoud Vedadi, Heng Ma, Arvind Ramanathan and 9 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Monica Rosas-LemusDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 United States.
Sudhakar AtheDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637 United States.
George MinasovDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 United States.
Jason A PattieDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 United States.
Joseph S BrunzelleCenter for Structural Biology of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 United States.ORCID https://orcid.org/0000-0001-9197-0018
Irene ChauStructural Genomics Consortium, University of Toronto, Toronto ON M5S 1A8 Canada.
Fengling LiStructural Genomics Consortium, University of Toronto, Toronto ON M5S 1A8 Canada.
Masoud VedadiDepartment of Pharmacology and Toxicology, University of Toronto, Toronto ON M5S 1A8 Canada.
Heng MaData Science and Learning Division, Argonne National Laboratory, Lemont, Illinois 60439 United States.
Arvind RamanathanData Science and Learning Division, Argonne National Laboratory, Lemont, Illinois 60439 United States.ORCID https://orcid.org/0000-0002-1622-5488
Mark E BeckerDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 United States.
Thomas J HopeDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 United States.
Hazem AbdelkarimDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois-Chicago, Chicago, Illinois 60607 United States.
Patrick GrudzienDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois-Chicago, Chicago, Illinois 60607 United States.
Vadim GaponenkoDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois-Chicago, Chicago, Illinois 60607 United States.
Jeffrey E MontgomeryDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637 United States.
Raymond E MoelleringDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637 United States.ORCID https://orcid.org/0000-0002-2043-7838
Viresh H RawalDepartment of Chemistry, University of Chicago, Chicago, Illinois 60637 United States.ORCID https://orcid.org/0000-0003-4606-0239
Karla J F SatchellDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 United States.ORCID https://orcid.org/0000-0003-3274-7611

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2017 to 2026
$24.9M
TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7M
Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
NIAID NIH HHS 75N93022C00035NIAID NIH HHS HHSN272201700060CNIAID NIH HHS U01 AI124316NIGMS NIH HHS P20 GM121176NIH HHS 75N93022C00035
6 · The paper itself

Abstract

To address the ongoing threat of SARS-CoV-2 and potential emergence of novel coronaviruses, we employed a comprehensive strategy to identify and synthesize inhibitors of coronavirus methyltransferases with chemical analogs of

Indexed as

Coronavirusmethyltransferasensp14SAHSARS-CoV-2

Identifiers

PMID41568342
PMCPMC12818953

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.