ArticleJournal of the American Heart Association2026
Elevated ANGPTL8 (Angiopoietin-Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline.Aging cell · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundANGPTL8 (angiopoietin-like protein 8) regulates lipid metabolism, but its role in atherosclerosis among patients with type 2 diabetes, particularly through lipid-independent mechanisms, remains unclear.
methodsThis matched case-control study included 202 patients with type 2 diabetes (101 with atherosclerosis, and 101 without) matched for age, body mass index, and sex. Atherosclerosis was assessed via carotid intima-media thickness and plaque scores. Circulating ANGPTL8 levels were measured by ELISA. Associations were evaluated using multivariate logistic regression, restricted cubic splines, and mediation analyses.
resultsPatients with atherosclerosis had significantly higher circulating ANGPTL8 levels (529.96 [350.58-816.78] versus 470.62 [265.54-717.47] pg/mL;
conclusionsElevated ANGPTL8 levels are independently associated with increased atherosclerosis risk in patients with type 2 diabetes. This relationship is partially mediated through cystatin C but not lipid parameters. ANGPTL8 significantly improves cardiovascular risk prediction beyond traditional risk factors, suggesting its potential as a novel biomarker for cardiovascular risk stratification and a therapeutic target addressing residual cardiovascular risk through lipid-independent inflammatory pathways in type 2 diabetes.
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Registered trials
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