In one paragraphArticle in Circulation. Heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
22 authors.
Justin B Echouffo-TcheuguiDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, MD (J.B.E.-T.).ORCID 0000-0002-8460-1617 Chiadi E NdumeleDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (C.E.N., W.S.P.).ORCID 0000-0002-1603-282X Jingsha ChenDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.B.E.-T., J. Chen, M.R.R., K.M., E.S.).
Mary R RooneyDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.B.E.-T., J. Chen, M.R.R., K.M., E.S.).ORCID 0000-0002-5607-4848 Keenan A WalkerLaboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD (K.A.W.).
Pascal SchlosserDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (P.S.).ORCID 0000-0002-8460-0462 Kuni MatsushitaDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.B.E.-T., J. Chen, M.R.R., K.M., E.S.).ORCID 0000-0002-7179-718X Christie C BallantyneSection of Cardiovascular Research, Baylor College of Medicine, Houston, TX (C.C.B., R.C.H.).ORCID 0000-0002-6432-1730 Ron C HoogeveenSection of Cardiovascular Research, Baylor College of Medicine, Houston, TX (C.C.B., R.C.H.).ORCID 0000-0003-2399-4653 Eric BoerwinkleDepartment of Epidemiology, UTHealth School of Public Health, Houston, TX (E.B., B.Y.).ORCID 0000-0001-8813-0544 Amil M ShahDivision of Cardiovascular Medicine, Department of Medicine (A.M.S.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0003-1056-4451 Ruth F DubinDivision of Nephrology, Department of Medicine (R.F.D.), University of Texas Southwestern Medical Center, Dallas.ORCID 0000-0002-0498-1980 Jerome I RotterDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T).ORCID 0000-0001-7191-1723 Kent D TaylorDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T).ORCID 0000-0002-2756-4370 Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (C.E.N., W.S.P.).ORCID 0000-0002-8655-5204 Peter GanzDivision of Cardiology, Zuckerberg San Francisco General Hospital and Department of Medicine, University of California, San Francisco (P.G.).ORCID 0000-0002-0437-8882 Elizabeth SelvinDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.B.E.-T., J. Chen, M.R.R., K.M., E.S.).ORCID 0000-0001-6923-7151 Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7MMapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MDiabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K23 HL153774NHLBI NIH HHS K24 HL152008NHLBI NIH HHS K24 HL152440NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL135008NHLBI NIH HHS R01 HL146907NHLBI NIH HHS R01 HL148218NIDDK NIH HHS K01 DK141963NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK089174
6 · The paper itselfAbstract
backgroundTo investigate the proteomic signatures of heart failure (HF) in diabetes. The underlying mechanisms of the elevated risk of HF in diabetes are unknown.
methodsIn 10 189 ARIC study (Atherosclerosis Risk in Communities) participants free of HF (mean age 57±7 years, 56% women, 22% Black adults, 14% with diabetes), we conducted discovery and internal validation for the associations of 4955 plasma proteins with HF by diabetes status. We performed (1) Cox regression to identify proteins associated with HF by diabetes status, (2) external validation in the MESA study (Multi-Ethnic Study of Atherosclerosis, n=5233, 633 with diabetes), and (3) pathway analyses for identified proteins.
resultsOver 24 years in ARIC, there were 2417 HF events (605 among individuals with diabetes). In 993 individuals with diabetes in the discovery sample, 19 proteins were associated with HF (
conclusionsWe identified 5 proteomic markers (4 novel) uniquely related to HF risk among individuals with diabetes and not among those without diabetes.
Indexed as
AtherosclerosisBlood ProteinsDiabetes MellitusHeart FailureProteomicsAgedBiomarkersFemaleHumansMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsUnited StatesBiomarkersBlood Proteinscartilagediabetes mellitus, type 2heart failureleucineproteomicstyrosine
Identifiers
PMID41569286
PMCPMC12981341
What Socratic holds
Textmetadata
LicenceTDM
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