ReviewBiological trace element research2026
Zinc and Copper Metallic Instability: Investigating Altered Metal Functionality in both Human and Animal Studies.
Review in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeostasis is the regulatory mechanism for the expression of all genes, the function of all metabolic pathways, the utilization of any essential trace element (TEs), while its disruptions lead to many pathological states. The pathologies include cardiovascular disease, anaemia, diabetes, neurological disorders, and cell death. For this, copper and zinc are two of the major TEs involved in controlling the physiological and pathological processes in both humans and animals. Zinc deficiency, for instance, is linked with decreased body weight, decreased ability to metabolize glucose, and impaired immune function. By contrast, deficiency of copper can lead to several neurological disorders, oxidative stress, mitochondrial dysfunction, and changes in lipid metabolism. On the other hand, there excessive exposure can have adverse effects on health, including the development of epilepsy, neuronal excitability, genotoxic effects, and cellular toxicity. Moreover, dual biological functions of zinc further complicate the understanding of their roles in both health and disease. Such as, zinc has a neuromodulatory function and helps to control excitably in neurons, but sometimes zinc in the synapse, inhibit the functioning of inhibitory neurotransmitter and cause damage to the neurons. Likewise, in metabolic diseases, particularly diabetes mellitus, there is often dysregulation of the levels of zinc and copper, resulting in steel-like interactions; elevated levels of copper and reduced levels of zinc contribute towards the pathogenesis of both the disease and the progression of dementia. Despite this antagonistic relationship, both trace metals act synergistically as necessary derivatives of superoxide dismutase; therefore, both play a vital role in maintaining cellular antioxidant defense systems. Therefore, this review covers published articles from 1992-2025 with regard to zinc and copper in their dietary and nanoparticle forms in animal and human models to demonstrate their differing roles and how they complement one another, or conflict with one another.
Indexed as
Identifiers
41569441What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.