Evidence map›Paper›PMID 41569485›Full record

ReviewAdvances in neurobiology2026

Synaptic Cell Adhesion: A Structural Perspective.

Sumit J Bandekar, Szymon P Kordon, Demet Araç

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sumit J BandekarDepartment of Biochemistry and Molecular Biology, University of Chicago Neuroscience Institute, Institute for Biophysical Dynamics, and Center for Mechanical Excitability, University of Chicago, Chicago, IL, USA.
Szymon P KordonDepartment of Biochemistry and Molecular Biology, University of Chicago Neuroscience Institute, Institute for Biophysical Dynamics, and Center for Mechanical Excitability, University of Chicago, Chicago, IL, USA.
Demet AraçDepartment of Biochemistry and Molecular Biology, University of Chicago Neuroscience Institute, Institute for Biophysical Dynamics, and Center for Mechanical Excitability, University of Chicago, Chicago, IL, USA. arac@uchicago.edu.

Funding

Structural and Functional Studies of Cell-Adhesion ReceptorsR35GM148412 · NIGMS · UNIVERSITY OF CHICAGO · PI Demet Arac-Ozkan · 2023 to 2026
$2.2M
Structural and Functional Characterization of CELSR-subfamily adhesion G protein-coupled receptorsK99GM157487 · NIGMS · UNIVERSITY OF CHICAGO · PI Sumit Bandekar · 2025 to 2026
$218k
Structure, Function, and Antibody-based Modulation of GPR126: Regulation of an Adhesion GPCR by its Extracellular RegionF32GM142266 · NIGMS · UNIVERSITY OF CHICAGO · PI BANDEKAR, SUMIT · 2021 to 2023
$205k
NIGMS NIH HHS F32 GM142266NIGMS NIH HHS K99 GM157487NIGMS NIH HHS R35 GM148412
6 · The paper itself

Abstract

Cell adhesion molecules (CAMs) play critical roles in mediating intercellular interactions in the context of the nervous system, such as guiding neuronal development, synapse formation and maturation, and synaptic plasticity. In addition to their extracellular adhesive roles, most CAMs induce intracellular signaling events and scaffold large protein complexes through intracellular domains. The molecular biology of how CAMs regulate synaptic development and function has been hugely advanced by decades of structural biology. These structures have illuminated multiple modes of CAM regulation, including how alternative splicing regulates CAM homotypic and heterotypic interactions. CAMs are diverse in size and contain a variety of adhesion domain classes such as immunoglobulin (Ig), leucine-rich repeats (LRR), and laminin G/neurexin/sex hormone (LNS). In this chapter, we detail structures of key synaptic adhesion complexes, including a mechanistic explanation of how these structures have informed functional work. Detailing the structural basis of synaptic adhesion provides a foundation for deciphering the complex interactions underlying neuronal connectivity and function in health and disease.

Indexed as

Cell AdhesionCell Adhesion MoleculesSynapsesAlternative SplicingAnimalsHumansNeurexinsNeurodevelopmentNeuronal PlasticitySignal TransductionCell Adhesion MoleculesNeurexinsAdhesion GPCRAlternative splicingCell adhesion moleculeLatrophilinSignalingSynapse

Identifiers

PMID41569485
PMCPMC13225310

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.