ArticleDiabetes & vascular disease research
The association between hypoglycemia and panvascular disease in type 2 diabetes patients: The correlation structure mediated by inflammatory and metabolic abnormalities.
Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundHypoglycemia in type 2 diabetes patients is associated with metabolic abnormalities and inflammation that affect vascular beds. The relationship between hypoglycemia and panvascular disease (PVD) is not clear. This study aimed to investigate the association between PVD and hypoglycemia, and to identify potential mediators.MethodThis retrospective cross-sectional study enrolled Patients from two centers in Chongqing China, and the results were further validated using UK Biobank data. Logistic regression was used to test the association of hypoglycemia and PVD. Stratification and interaction analyses to test the effects across study subgroups. Forward (hypoglycemia to PVD) and reverse (PVD to hypoglycemia) relationships were analyzed by structural equation modeling (SEM), which included interleukin-6, neutrophil-to-lymphocyte ratio, uric acid, hemoglobin A1c, and systolic blood pressure.Results22,128 patients diagnosed with T2DM at two large centers and 44442 T2DM participants from the UK Biobank were enrolled. A significant association between hypoglycemia and PVD was found. Subgroup analysis found hypoglycemia was more strongly associated with PVD in patients with inflammatory abnormalities and metabolic dysfunction. SEM suggested a correlation structure between hypoglycemia and PVD which might mutually aggravated each other through inflammation and metabolism pathways.ConclusionThis is the first study that described the correlation structure between hypoglycemia and PVD with a large population. Within this potential mutual association, inflammation and metabolism might be mediators. Our study also highlights the insufficient attention clinicians pay to hypoglycemia and PVD, and further attention is needed in future clinical practice and research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.