Evidence map›Paper›PMID 41570521›Full record

ArticlePsychoneuroendocrinology2026

Chemotherapy-induced estradiol reduction is associated with less relief of pre-chemotherapy anxiety in breast cancer patients.

Ángela Del Águila, Lindsay D Strehle, Seth Adarkwah Yiadom, Sagar D Sardesai, Nicole O Williams, Margaret E Gatti-Mays, Daniel G Stover, Preeti K Sudheendra, Robert Wesolowski, Stephanie M Gorka and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ángela Del ÁguilaInstitute of Brain, Behavior and Immunology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Lindsay D StrehleInstitute of Brain, Behavior and Immunology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Seth Adarkwah YiadomDivision of Biostatistics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sagar D SardesaiDivision of Medical Oncology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Nicole O WilliamsDivision of Medical Oncology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Margaret E Gatti-MaysDivision of Medical Oncology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Daniel G StoverDivision of Medical Oncology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Preeti K SudheendraDivision of Medical Oncology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Robert WesolowskiDivision of Medical Oncology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Stephanie M GorkaInstitute of Brain, Behavior and Immunology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Psychiatry and Behavioral Health, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Rebecca R AndridgeDivision of Biostatistics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Leah M PyterInstitute of Brain, Behavior and Immunology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Psychiatry and Behavioral Health, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: leah.pyter@osumc.edu.

Funding

(PQ #10) Gut-brain interactions underlying chemotherapy-induced behavioral comorbiditiesR01CA216290 · NCI · OHIO STATE UNIVERSITY · PI PYTER, LEAH M · 2017 to 2021
$2.1M
NCI NIH HHS R01 CA216290
6 · The paper itself

Abstract

Chemotherapy-induced apoptosis of mature ovarian follicles in breast cancer patients likely results in decreased circulating estradiol (E

Indexed as

AnxietyBreast NeoplasmsEstradiolAdultAgedAntineoplastic AgentsDepressionFemaleHumansMiddle AgedUncertaintyAntineoplastic AgentsEstradiolDepressive symptomsEstrogenIntolerance of uncertaintyState anxietyTrait anxiety

Identifiers

PMID41570521
PMCPMC13312206

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.