Evidence map›Paper›PMID 41570985›Full record

ArticleThe Journal of biological chemistry2026

A new family of TonB-dependent copper transporters linked to respiratory oxidase function.

Majda Hachmi, Manon Mirgaux, René Wintjens, Chloé Carassus, Pascal Arnoux, Gauthier Roy, Alex Rivera-Millot, Stéphanie Slupek, Anne-Sophie Debrie, Véronique Alaimo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CrpH ofFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Majda HachmiUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Manon MirgauxUniversité Libre de Bruxelles, Faculty of Pharmacy, Department of Research in Drug Development, Unit of Microbiology, Bioorganic and Macromolecular Chemistry, Bruxelles, Belgium.
René WintjensUniversité Libre de Bruxelles, Faculty of Pharmacy, Department of Research in Drug Development, Unit of Microbiology, Bioorganic and Macromolecular Chemistry, Bruxelles, Belgium.
Chloé CarassusAix Marseille University, CEA, CNRS, BIAM, Saint-Paul-lez-Durance, France.
Pascal ArnouxAix Marseille University, CEA, CNRS, BIAM, Saint-Paul-lez-Durance, France.
Gauthier RoyUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Alex Rivera-MillotUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Stéphanie SlupekUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Anne-Sophie DebrieUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Véronique AlaimoCNRS, UMR8516 Laboratoire de Spectroscopie pour les Interactions, la Réactivité et l'Environnement, Université de Lille, Lille, France.
Gabriel BillonCNRS, UMR8516 Laboratoire de Spectroscopie pour les Interactions, la Réactivité et l'Environnement, Université de Lille, Lille, France.
Loïc CoutteUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Rudy AntoineUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France. Electronic address: rudy.antoine@pasteur-lille.fr.
Françoise Jacob-DubuissonUniversity of Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France. Electronic address: francoise.jacob@cnrs.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper is an essential metal notably found in respiration complexes for its redox properties. It is also toxic hence its cellular trafficking is tightly controlled. Bacteria have developed a number of defense systems against copper excess, but its acquisition pathways remain poorly characterized. Ubiquitous in Gram-negative bacteria, TonB-dependent transporters (TBDTs) are outer membrane β-barrel proteins that mediate the proton motive force-dependent import of various nutrients to the periplasm. Here, we characterized a TBDT that imports copper in the whooping cough agent Bordetella pertussis, CrtA

Indexed as

Bacterial ProteinsBordetella pertussisCopperMembrane ProteinsOxidoreductasesCrystallography, X-RayModels, MolecularBacterial ProteinsCopperMembrane ProteinsOxidoreductasestonB protein, BacteriaBordetella pertussiscopper transportcrystal structuremembrane proteinouter membranerespiratory oxidasessequence similarity networkTonB-dependent transporter

Identifiers

PMID41570985
PMCPMC12914433

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.