SynthesisDie Anaesthesiologie2026
Effect of intrathecal morphine compared with truncal nerve blocks on postoperative analgesia in adults : A meta-analysis of randomized controlled trials.
Synthesis in Die Anaesthesiologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBalancing effective postoperative analgesia with reduced opioid use is crucial in the context of the opioid crisis.
objectiveThis meta-analysis compares intrathecal morphine (ITM) and truncal nerve blocks (TNBs) to address this challenge.
methodsRandomized controlled trials (RCTs) comparing ITM with TNBs were included. Databases searched included CENTRAL, Embase, PubMed, Scopus and Web of Science. Primary outcomes were total opioid consumption within 24 h postoperatively, with secondary outcomes including 48‑h opioid use, pain intensity and postoperative nausea and vomiting (PONV). Effect sizes were estimated using a random effects model with mean difference (MD), standardized mean difference (SMD), or relative risk (RR) and 95% confidence intervals (CIs).
resultsIn total, 13 RCTs involving 834 participants were included. The use of ITM significantly reduced opioid consumption at 24 h (SMD: -1.27, 95% CI -2.32, -0.21, P = 0.0185) and 48 h (SMD: -1.01, 95% CI -1.89, -0.13, P = 0.0248) and also lowered resting pain scores at 12 h (MD: -1.05, 95% CI -1.74, -0.36, P = 0.0029) and 24 h (MD: -0.62, 95% CI -1.07, -0.18, P = 0.0062) postoperatively. For dynamic pain, ITM was more effective than TNB at 12 h (MD: -1.33, 95% CI -2.09, -0.57, P = 0.0006) and 24 h (MD: -0.59, 95% CI -1.05, -0.13, P = 0.0128); however, ITM was associated with a higher incidence of PONV (RR: 3.26, 95% CI 1.55, 6.83, P = 0.0018).
conclusionIn comparison to TNBs the use of ITM in relatively high dosages (5-10 μg/kg) provides statistically superior analgesia and reduces opioid use within 24 h postoperatively but its association with increased PONV warrants cautious interpretation and further study.
Indexed as
Identifiers
41572033What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.