ArticleCardiovascular ultrasound2026
Prognostic and functional value of left atrial indices in advanced heart failure.
Article in Cardiovascular ultrasound, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft atrial (LA) remodeling and dysfunction are increasingly recognized as important contributors to outcomes in heart failure; however, their prognostic and functional relevance in advanced heart failure (AHF) remains insufficiently defined. This study evaluated the prognostic and functional significance of echocardiographic LA indices in AHF.
methodsBetween 2021 and 2023, 194 patients with left ventricular ejection fraction ≤ 25% were included. All patients were referred to our tertiary cardiovascular center for evaluation of advanced therapeutic options [left ventricular assist device (LVAD) or heart transplantation] and underwent echocardiography, right heart catheterization, and cardiopulmonary exercise testing (CPET). Kaplan–Meier and Cox regression analyses were used to assess the prognostic impact of LA strain and mechanical indices on the composite endpoint of all-cause death, LVAD implantation, or heart transplantation. Correlations with CPET parameters were examined to evaluate functional relevance.
resultsPatients with impaired LA reservoir strain (LASr < 8.35%) exhibited more advanced atrial remodeling, higher filling pressures, worse ventricular function, and reduced exercise capacity. During a median follow-up of 461 days, adverse outcomes occurred more frequently in the lower LASr group (35.1% vs. 14.4%, p = 0.002). Both LASr and LA minimum volume index (LAVImin) independently predicted the composite endpoint and provided incremental prognostic value. LASr, LA ejection fraction (LAEF), and LA expansion index (LAEI) showed positive associations with peak VO₂ (all p < 0.001), indicating an association between atrial mechanics and exercise performance.
conclusionsIn patients with AHF, LASr and LAVImin are independently associated with adverse clinical outcomes and reduced exercise tolerance. Incorporation of LA functional assessment into routine evaluation may help improve risk stratification and support clinical decision-making in this high-risk population.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.