Evidence map›Paper›PMID 41572508›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2.

Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Risheng ZhaoDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Xiaoli CuiDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Huizhu DuPeking University People's Hospital, Qingdao; Women and Children's Hospital, Qingdao University, Qingdao, P. R. China.
Zhuoqun WangDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Chang LiuDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Linxin ZhangDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Jianing QiDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Di YangDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Hui YuDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Shuang YanDepartment of Ultrasonography, Integrated Traditional Chinese and Western Medicine Hospital of Jilin City Jilin Province, Jilin, P. R. China.
Wei LiuDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Haiming SunDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.
Mengyang WangDepartment of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin, P. R. China.ORCID https://orcid.org/0009-0007-7340-1568

Funding

National Natural Science Foundation of China 82404625Natural Science Foundation of Jilin Provincial Department of Science and Technology YDZJ202501ZYTS195
6 · The paper itself

Abstract

Pathological cardiac hypertrophy is a major predisposing factor for heart failure (HF). This study investigates the role of the E3 ubiquitin ligase Tripartite Motif-Containing 40 (TRIM40) in cardiac hypertrophy. Using TRIM40 knockout (TRIM40

Indexed as

CardiomegalyHeart FailureTripartite Motif ProteinsUbiquitin-Protein LigasesAngiotensin IIAnimalsDisease Models, AnimalMaleMiceMice, KnockoutProtein Kinase CUbiquitinationAngiotensin IIProtein Kinase Cprotein kinase NTripartite Motif ProteinsUbiquitin-Protein Ligasesangiotensin IIcardiac hypertrophyheart failurePKN2transverse aortic constrictionTRIM40

Identifiers

PMID41572508
PMCPMC13042792

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.