Evidence map›Paper›PMID 41572576›Full record

Observational studyBJOG : an international journal of obstetrics and gynaecology2026

Sexual Function, Activity and Distress 24 Months After Surgical Menopause: What Happens After Menopause (WHAM)-A Prospective Controlled Study.

Martha Hickey, Trevor Tejada-Berges, Susan M Domchek, Efrosinia O Krejany, Alison Brand, Peixuan Li, Sabine Braat, Sheryl Kingsberg

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martha HickeyDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and the Royal Women's Hospital, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-3941-082X
Trevor Tejada-BergesGynaecological Oncology Service, Chris O'Brien Lifehouse, Sydney, Australia.
Susan M DomchekBasser Center for BRCA, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5914-7272
Efrosinia O KrejanyDepartment of Obstetrics, Gynaecology and Newborn Health, the Royal Women's Hospital, Melbourne, Victoria, Australia.
Alison BrandUniversity of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-7975-6326
Peixuan LiCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0003-0782-2341
Sabine BraatCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0003-1997-3999
Sheryl KingsbergDepartment of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Funding

Australia New Zealand Gynaecological Oncology GroupBasser Center for BRCANational Health and Medical Research CouncilPeter MacCallum Cancer CentreRoyal Melbourne HospitalSusan G. Komen OrganizationThe Royal Women's HospitalThe Women's FoundationUniversity of MelbourneUniversity of New South WalesUniversity of PennsylvaniaUniversity of QueenslandWestmead Hospital Familial Cancer Service
6 · The paper itself

Abstract

objectiveTo determine the effect of surgical menopause (risk-reducing salpingo-oophorectomy, RRSO) on sexual function and the modifying effects of HRT.

designProspective observational study of women undergoing RRSO and age-matched comparison group who retained their ovaries.

settingHigh-risk clinics and general population.

methodsSexual function was measured at baseline, 3, 6, 12 and 24 months.

main outcome measuresPrimary outcome was sexual function at 24 months using the Female Sexual Function Index (FSFI). Secondary outcomes included the Fallowfield Sexual Activity Questionnaire (SAQ) and Female Sexual Distress Scale-Revised (FSDS-R).

resultsBaseline sexual function was similar between groups. At 24 months, sexual dysfunction increased from 19% to 42% after RRSO versus 24% to 29% in comparisons (Odds Ratio (OR) 1.9, 95% CI 0.7-5.1; p = 0.21). Compared to comparisons, sexual desire (-0.4, p = 0.02), arousal (-0.7, p < 0.001), lubrication (-0.6, p = 0.01) and satisfaction (-0.6, p < 0.001) were significantly reduced in the RRSO group. Sexual pain (-0.5, p = 0.05) and discomfort (-1.0, p < 0.001) increased after RRSO; sexual habit was unchanged. Sexual distress nearly quadrupled in the RRSO group (OR 3.7, 95% CI 1.6-9.0; p = 0.003). After RRSO, 61% commenced HRT. HRT was not associated with sexual function, activity or distress.

conclusionsSexual dysfunction and distress increased after RRSO. Use of HRT was not associated with better sexual function.

Indexed as

Salpingo-oophorectomySexual BehaviorSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalAdultEstrogen Replacement TherapyFemaleHumansMenopauseMiddle AgedProspective StudiesSurveys and QuestionnairesHRTrisk‐reducing salpingo‐oophorectomyRRSOsexual functionsurgical menopause

Identifiers

PMID41572576
PMCPMC13040429

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.