Evidence map›Paper›PMID 41572801›Full record

ArticleInternational journal of stem cells2026

Exosomes from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells Protect Lung Epithelium and Attenuate Fibrosis.

Sangryul Cha, Jooyeon Lee, Jimin Jang, Yeongcheol Kim, Dahee Han, Seok-Ho Hong, Seung-Jin Kim, Dae-Hee Lee, Chung Hyeun Ma, Han Pil Lee and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sangryul ChaDepartment of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-9447-6434
Jooyeon LeeDepartment of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-4681-7046
Jimin JangDepartment of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-1796-2164
Yeongcheol KimDepartment of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0009-0004-6742-8287
Dahee HanDepartment of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0009-0000-5694-0980
Seok-Ho HongDepartment of Internal Medicine, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-3372-442X
Seung-Jin KimDepartment of Biochemistry, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-6062-1736
Dae-Hee LeeDepartment of Marine Bio Food Science, Gangneung-Wonju National University, Gangneung, Korea.ORCID https://orcid.org/0000-0002-8960-1632
Chung Hyeun MaDepartment of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.ORCID https://orcid.org/0000-0002-7005-1079
Han Pil LeeDepartment of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-4234-1220
Se-Ran YangDepartment of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-2422-213X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterized by maladaptive epithelial-mesenchymal crosstalk and progressive extracellular matrix accumulation, whereas currently available antifibrotic agents merely decelerate functional decline. This study investigated whether exosomes derived from human mesenchymal stem cells derived from embryonic stem cells (ESC-MSCs) restore epithelial stress responses and attenuate fibrotic remodeling. Human IPF lung transcriptomes were integrated with a bleomycin-induced murine model analyzed by RNA sequencing and protein signaling, together with cigarette smoke extract-induced injury in A549 epithelial cells. ESC-MSCs-derived exosomes exhibited typical morphology and size distribution, enrichment of tetraspanins, and absence of endoplasmic reticulum contamination, consistent with high-purity preparations. Across human IPF and bleomycin-injured lungs, transcriptomic profiling revealed prominent enrichment of extracellular matrix and cytoskeletal gene programs, whereas mitogen-activated protein kinase (MAPK) and Smad families displayed only modest alterations at the mRNA level.

Indexed as

Epithelial stress signalingExosomesExtracellular matrix remodelingIdiopathic pulmonary fibrosisMesenchymal stem cells derived from embryonic stem cellsTranscription factor AP-1

Identifiers

PMID41572801
PMCPMC12954767

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.