Evidence map›Paper›PMID 41573011›Full record

ArticleInternational journal of ophthalmology2026

Altered amplitudes of low-frequency fluctuations in primary open angle glaucoma patients: a resting-state fMRI study.

Yi Huang, Hong-Dou Luo, Yong-Qiang Shu, Feng Ouyang, Yu-Ning Song, Yuan-Yuan Wang, Xue-Qing Yu, Chan Xiong, Lu Yang, Xu Zhang

Abstract read
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In one paragraph

Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yi HuangAffiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang 330006, Jiangxi Province, China.
Hong-Dou LuoAffiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang 330006, Jiangxi Province, China.
Yong-Qiang ShuDepartment of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University; PET Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Feng OuyangDepartment of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University; PET Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Yu-Ning SongAffiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang 330006, Jiangxi Province, China.
Yuan-Yuan WangDepartment of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University; PET Center, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Xue-Qing YuAffiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang 330006, Jiangxi Province, China.
Chan XiongAffiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang 330006, Jiangxi Province, China.
Lu YangAffiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang 330006, Jiangxi Province, China.
Xu ZhangAffiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang 330006, Jiangxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the relationships between amplitude of low-frequency fluctuations (ALFF) changes and clinical ophthalmic parameters in patients with primary open angle glaucoma (POAG) and analyze the diagnostic value of ALFF.

methodsTwenty-four POAG patients and 24 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI). Nonparametric rank-sum tests were used to compare the ALFF values in the slow-4 and slow-5 bands, and Spearman or Pearson correlation analysis was used to assess the correlation between ALFF changes and clinical ophthalmic parameters in POAG patients. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the ALFF.

resultsThere were 16 males in POAG patients (median age 48y) and 12 males in HCs (median age 39y). Compared with HCs, POAG patients presented increased or decreased ALFF values in different brain regions, and similar changes were observed in mild POAG patients. The ALFF values were correlated with retinal nerve fiber layer (RNFL) thickness, inner limiting membrane-retinal pigment epithelium thickness changes and the degree of visual field defects. Analysis of the diagnostic value of the ALFF

conclusionPOAG patients present altered cortical function that is significantly correlated with the optic nerve and retinal thickness and had good diagnostic value, which may reflect the underlying neuropathological mechanism of POAG.

Indexed as

low-frequency amplitudeneurodegenerative diseaseprimary open angle glaucomaresting-state functional magnetic resonance imaging

Identifiers

PMID41573011
PMCPMC12820637

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.