ArticleFrontiers in endocrinology2025
Cangfu Daotan decoction treats PCOS-IR through the IL6/JAK2/STAT3/FOXO4 signaling pathway.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to investigate the protective effects and underlying mechanisms of Cangfu Daotan Decoction (CDD) in both Materials and methods: Active compounds in CDD were identified using UPLC-HRMS. Network pharmacology and molecular docking analyses were employed to predict key molecular targets. A nd a high-fat diet. Results: Fifteen active compounds in CDD were preliminarily identified. Ninety-four potential target genes related to the treatment of PCOS-IR were screened. Network pharmacology and molecular docking analyses indicated strong binding affinities between STAT3 and several active compounds of CDD. CDD improved ovarian function and reduced insulin resistance in PCOS model mice. Conclusion: CDD may improve ovarian function and insulin resistance in PCOS-IR mice by modulating the IL6/JAK2/STAT3/FOXO4 signaling pathway.
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