Evidence map›Paper›PMID 41573248›Full record

ReviewBioMed research international2026

Harnessing Phase Separation in the Extracellular Matrix: From Mechanisms to Therapeutic Opportunities.

Runhan Guo, Jiayi Li, Xuenan Wang, Huabao Xiong, Fei Wu, Tao Zhong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Runhan GuoInstitute of Immunology and Molecular Medicine, Key Laboratory of Cell and Biomedical Technology of Shandong Province, School of Basic Medical Sciences, Jining Medical University, Jining, China, jnmc.edu.cn.ORCID https://orcid.org/0009-0005-3315-7770
Jiayi LiInstitute of Immunology and Molecular Medicine, Key Laboratory of Cell and Biomedical Technology of Shandong Province, School of Basic Medical Sciences, Jining Medical University, Jining, China, jnmc.edu.cn.ORCID https://orcid.org/0009-0005-3851-5979
Xuenan WangAffiliated Hospital of the Jining Medical University, Jining, Shandong, China.ORCID https://orcid.org/0000-0001-8761-2154
Huabao XiongInstitute of Immunology and Molecular Medicine, Key Laboratory of Cell and Biomedical Technology of Shandong Province, School of Basic Medical Sciences, Jining Medical University, Jining, China, jnmc.edu.cn.ORCID https://orcid.org/0000-0003-0180-2104
Fei WuDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, sph.com.cn.ORCID https://orcid.org/0000-0001-6689-6135
Tao ZhongInstitute of Immunology and Molecular Medicine, Key Laboratory of Cell and Biomedical Technology of Shandong Province, School of Basic Medical Sciences, Jining Medical University, Jining, China, jnmc.edu.cn.ORCID https://orcid.org/0000-0003-3898-057X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular matrix (ECM) constitutes a sophisticated network that is paramount in preserving tissue integrity and modulating cellular behaviors. Recent revelations regarding phase separation provide a groundbreaking perspective on the ECM, elucidating how this phenomenon affects the spatial organization and functionality of its components. This review delves into the implications of phase separation in ECM-related pathologies and underscores its prospective role as a therapeutic target. By adeptly manipulating phase separation, pioneering therapeutic strategies can be devised to restore the equilibrium of the ECM, employing biomimetic materials and cutting-edge drug delivery systems to advance tissue repair and regeneration. Such innovative approaches hold the promise of enhancing treatment outcomes by directly addressing the molecular mechanisms that underpin ECM dysfunction. Ongoing research into phase separation is imperative for translating these insights into clinical applications, potentially transforming therapies for intricate ECM disorders and offering renewed hope for improved patient care.

Indexed as

Extracellular MatrixAnimalsBiomimetic MaterialsDrug Delivery SystemsHumansPhase Separationextracellular matrixphase separationtherapeutic strategies

Identifiers

PMID41573248
PMCPMC12820798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.