Evidence map›Paper›PMID 41573701›Full record

ArticleJournal of diabetes research2026

Yixiao Formula Suppresses Myocardial Fibrosis Through UpregulatingmiR-133a and Downregulating TGF-

Qiyao Zhao, Yalu Wen, Honghui Wu, Jiaoyue Li, Yunpeng Luo, Ping Li, Ye Zhang, Chaoyue Hu, Jukai Huang, Li Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiyao ZhaoDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.ORCID 0009-0007-6134-8122
Yalu WenDepartment of Respiratory Medicine, Beijing Hepingli Hospital, Beijing, China.
Honghui WuDepartment of Internal Medicine, Jingkai District, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.
Jiaoyue LiDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.ORCID 0009-0000-5923-9444
Yunpeng LuoDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.
Ping LiDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.
Ye ZhangDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.
Chaoyue HuDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.
Jukai HuangDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.
Li ZhangDepartment of Scientific Research, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.
Xiaohui YangDepartment of Nephrology and Endocrine (II), Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China, bucm.edu.cn.ORCID 0000-0001-9143-7328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Yixiao formula (YXF), a traditional Chinese herbal medicine, has demonstrated clinical efficacy in alleviating symptoms of diabetic cardiomyopathy (DCM). The therapeutic mechanism underlying YXF's effects on DCM remains poorly understood. Myocardial fibrosis is a key pathogenic mechanism in DCM, and previous studies have indicated that miR-133a may be involved in its progression. Given that the TGF- Objective: The main objective of this study is to investigate the potential contribution of the TGF- Materials and Methods: Spontaneously diabetic KKAy mice were used to establish a DCM model by continuous high-fat feeding, with C57BL/6 mice as controls. Echocardiography, body weight, and blood glucose data were collected every 4 weeks to examine the effects of YXF on blood glucose levels and changes in cardiac function and structure in DCM mice. Immunohistochemistry, RT-qPCR, and western blot were used to detect the expression levels of the TGF- Results: YXF improved fasting blood glucose levels in DCM mice, promoted cardiac diastolic function, upregulated miR133a, and inhibited the expression of the TGF- Conclusion: Through this study, we found that YXF can increase miR133a and inhibit the expression of the TGF-

Indexed as

Diabetic CardiomyopathiesDrugs, Chinese HerbalMicroRNAsMyocardiumSmad ProteinsTransforming Growth Factor betaAnimalsDown-RegulationFibrosisMaleMiceMice, Inbred C57BLSignal TransductionUp-RegulationDrugs, Chinese HerbalMicroRNAsMirn133 microRNA, mouseSmad ProteinsTransforming Growth Factor betacardiac fibroblastsdiabetic cardiomyopathymiR133aTGF-β/Smadstraditional Chinese medicine

Identifiers

PMID41573701
PMCPMC12822571

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.