Evidence map›Paper›PMID 41573939›Full record

ArticlebioRxiv : the preprint server for biology2025

Prodromal pathogenesis of CLN7 Batten Disease revealed by multimodal biomarkers in macaques.

William A Liguore, Winde Hilven, Lili Lurye, Jordy Akkermans, Marion Decrop, Robert Zweig, Larry S Sherman, Jodi L McBride, Daniele Bertoglio, Alison R Weiss

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

William A LiguoreDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), Beaverton, OR, USA.ORCID 0000-0002-6853-1882
Winde HilvenBio-Imaging Lab, University of Antwerp, Belgium.
Lili LuryeDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), Beaverton, OR, USA.ORCID 0009-0008-8894-5338
Jordy AkkermansMolecular Imaging Center Antwerp (MICA), University of Antwerp, Belgium.ORCID 0000-0002-1533-9504
Marion DecropBio-Imaging Lab, University of Antwerp, Belgium.ORCID 0009-0005-7745-8188
Robert ZweigDivision of Comparative Medicine, Oregon National Primate Research Center (ONPRC), Beaverton, OR, USA.
Larry S ShermanDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), Beaverton, OR, USA.ORCID 0000-0001-6098-6551
Jodi L McBrideDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), Beaverton, OR, USA.ORCID 0000-0002-4816-7569
Daniele BertoglioBio-Imaging Lab, University of Antwerp, Belgium.ORCID 0000-0003-4205-5432
Alison R WeissDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), Beaverton, OR, USA.ORCID 0000-0002-1821-8193

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
A non-human primate resource for pre-clinical studies of neurodegenerative diseaseR24NS104161 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHERMAN, LARRY S. · 2018 to 2020
$1.2M
Biomarkers of Inflammation, Neurodegeneration and Age-Associated Cognitive ImpairmentK01AG078407 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WEISS, ALISON RUTH · 2022 to 2024
$579k
NIA NIH HHS K01 AG078407NIH HHS P51 OD011092NINDS NIH HHS R24 NS104161
6 · The paper itself

Abstract

Neuronal ceroid lipofuscinosis type 7 (CLN7) is a devastating paediatric neurodegenerative disorder with no cure and limited natural history data to guide therapeutic development. Here, we present the first multimodal characterization of prodromal and early-stage CLN7 disease in Japanese macaques carrying a spontaneous

Indexed as

Batten DiseaseCLN7MacaqueMRINeurodegenerationPET

Identifiers

PMID41573939
PMCPMC12822580

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.