Evidence map›Paper›PMID 41574036›Full record

ArticleEuropean heart journal. Digital health2026

Artificial intelligence methods to detect heart failure with preserved ejection fraction within electronic health records: an equitable disease detection model.

Jack Wu, Dhruva Biswas, Samuel Brown, Matthew Ryan, Brett S Bernstein, Brian Tam To, Tom Searle, Maleeha Rizvi, Natalie Fairhurst, George Kaye and 16 more

Abstract read
In one paragraph

Article in European heart journal. Digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Jack WuSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.ORCID https://orcid.org/0000-0001-6043-5450
Dhruva BiswasSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.
Samuel BrownSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.
Matthew RyanSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.
Brett S BernsteinSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.
Brian Tam ToCardiovascular Department, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK.
Tom SearleDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AB, UK.
Maleeha RizviSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.
Natalie FairhurstCardiovascular Department, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK.
George KayeCardiovascular Department, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK.
Ranu BaralCardiovascular Department, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK.
Dhanushan VijayakumarKing's College London GKT School of Medical Education, London WC2R 2LS, UK.
Daksh MehtaKing's College London GKT School of Medical Education, London WC2R 2LS, UK.
Narbeh MelikianSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.
Daniel SadoSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.ORCID https://orcid.org/0000-0002-7065-3942
Gerald Carr-WhiteGuy's and St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Phil ChowienczykGuy's and St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
James TeoCardiovascular Department, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK.ORCID https://orcid.org/0000-0002-6899-8319
Richard J B DobsonDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AB, UK.
Daniel I BromageSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.ORCID https://orcid.org/0000-0002-4243-5964
Thomas F LüscherGuy's and St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Ali VazirGuy's and St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Theresa A McDonaghSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.
Jessica WebbGuy's and St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
Ajay M ShahSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.ORCID https://orcid.org/0000-0002-6547-0631
Kevin O'GallagherSchool of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE5 9NU, UK.ORCID https://orcid.org/0000-0003-2218-4763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases, with high levels of morbidity and mortality. However, many patients who meet diagnostic criteria for HFpEF do not have a documented diagnosis, particularly in non-White populations where conventional risk scores may underestimate risk. Our aim was to develop and validate a diagnostic prediction model to detect HFpEF based on ESC criteria, AIM-HFpEF. Methods and results: We applied natural language processing (NLP) and machine learning methods to routinely collected electronic health record (EHR) data from a tertiary centre hospital trust in London, UK, to derive the AIM-HFpEF model. We then externally validated the model and performed benchmarking against existing HFpEF prediction models (H2FPEF and HFpEF-ABA) for diagnostic power on the entire external cohort and in patients of non-White ethnicity and patients from areas of increased socioeconomic deprivation. An XGBoost model combining demographic, clinical, and echocardiogram data showed strong diagnostic performance in the derivation dataset [ Conclusion: AIM-HFpEF represents a validated equitable diagnostic model for HFpEF, which can be embedded within an EHR to allow for fully automated HFpEF detection.

Indexed as

Electronic health recordsHeart failure with preserved ejection fractionPrediction model

Identifiers

PMID41574036
PMCPMC12821069

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.