Evidence map›Paper›PMID 41574141›Full record

ArticleNorthern clinics of Istanbul2025

In vivo antioxidant and anti-inflammatory effects of Myrtus communis against ionizing radiation-induced gastrointestinal injury: TROD-GROG-002 study.

Melisa Bagci Kilic, Melike Pekyurek Varan, Ozum Atasoy, Nagehan Ozyilmaz, Seren Ede Pazarbasi, Busra Ertas, Ali Sen, Cemile Ceylan, Tugba Tunali Akbay, Feriha Ercan and 1 more

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Article in Northern clinics of Istanbul, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melisa Bagci Kilic *Department of Radiation Oncology, Marmara University School of Medicine, Istanbul, Turkiye.
Melike Pekyurek VaranDepartment of Radiation Oncology, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkiye.
Ozum Atasoy *Department of Radiation Oncology, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkiye.
Nagehan Ozyilmaz *Department of Histology and Embryology, Marmara University School of Medicine, Istanbul, Turkiye.
Seren Ede PazarbasiPharmacy Services Program, Fenerbahce University Vocational School, Istanbul, Turkiye.
Busra ErtasDepartment of Pharmacology, Marmara University Faculty of Pharmacy, Istanbul, Turkiye.
Ali SenDepartment of Pharmacognosy, Marmara University Faculty of Pharmacy, Istanbul, Turkiye.
Cemile CeylanDepartment of Medical Physics, Yeditepe University, Istanbul, Turkiye.
Tugba Tunali AkbayDepartment of Biochemistry, Marmara University Faculty of Dentistry, Istanbul, Turkiye.
Feriha ErcanDepartment of Histology and Embryology, Marmara University School of Medicine, Istanbul, Turkiye.
Beste Melek AtasoyDepartment of Radiation Oncology, Marmara University School of Medicine, Istanbul, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the in vivo radioprotective effects of Myrtus communis (MC) on the gastrointestinal system.

methodsA total of 30 female rats were divided into four groups: i) Control; ii) irradiation (IR) only; iii) MC-pretreated; and iv) MC-treated. The rats received oral MC extract (100 mg/kg/day) for 4 days before exposure to 10 Gy IR or continued until sacrifice. On the fourth day of IR exposure, the rats were sacrificed, and histopathological and biochemical analyses were performed on the ileum, pancreas, and liver tissues.

resultsMalondialdehyde and myeloperoxidase levels decreased in both MC-treated groups, while glutathione levels and Na

conclusionThe results of this study demonstrate that MC significantly decreases ionizing radiation-induced oxidative and inflammatory damage in the gastrointestinal systems of rats. Therefore, it may be regarded as a new candidate with radioprotective potential for future clinical application.

Indexed as

ileumIonizing radiationliverMyrtus communispancreasrats

Identifiers

PMID41574141
PMCPMC12821131

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.