Evidence map›Paper›PMID 41574183›Full record

ReviewEpilepsy currents2026

Antiseizure Treatments and Liver Injury: Expect (and Prevent) the Unexpected.

Marjorie Bunch, Shilpa Klocke, Nicole Woodrich, Alfred Sidney Barritt, Sara Eyal

Abstract readReview
In one paragraph

Review in Epilepsy currents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marjorie BunchDepartment of Neurology, Albany Medical College, Albany, NY, USA.ORCID https://orcid.org/0000-0002-4629-8311
Shilpa KlockePharmacy, Kaiser Permanente Colorado, Denver, CO, USA.
Nicole WoodrichDepartment of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
Alfred Sidney BarrittUNC Liver Center, University of North Carolina, Chapel Hill, NC, USA.
Sara EyalInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0003-1275-6094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-induced liver injury remains a major concern in the pharmacological management of epilepsy. Antiseizure medication (ASM)-related liver injury has multiple phenotypes, and in the majority of cases it is "idiosyncratic," involving hypersensitivity reactions. Awareness of drug- and patient-related risk factors can help direct treatment selection, monitoring, and ASM discontinuation, when necessary. This article examines the typical patterns of ASM-induced liver injury, from mild elevations of hepatic enzymes to life-threatening conditions. We also discuss risk factors, means for preventing liver injury in people with epilepsy treated with ASMs, and emerging biomarkers.

Indexed as

antiseizure medicationsDRESSdrug-induced liver injuryhepatotoxicityhypersensitivity reactionsliver testsSJS/TEN

Identifiers

PMID41574183
PMCPMC12819122

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.