ReviewFrontiers in physiology2025
Cold exposure and the cardiovascular system: from physiological adaptation to pathological risk.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Lipoprotein(a) as a Predictor of Major Adverse Cardiovascular Events in Patients with Acute Coronary Syndrome.Journal of clinical medicine · 2026Article
- A Healthy Lifestyle Can Slow Immune System Aging and Reduce Age-Related Chronic Inflammation: A Narrative Review.International journal of molecular sciences · 2026Review
- Cardiovascular disease mortality attributable to monthly non-optimal temperature in the united states: a county-level analysis.American journal of preventive cardiology · 2026Article
- Mortality risk due to non-optimum temperatures by cause of death, age, and sex: a multi-country time-series study.EClinicalMedicine · 2026Article
- Epidemiological Characteristics of Acute Coronary Syndrome Patients at Ogulin General Hospital over a Ten-Year Period.Journal of clinical medicine · 2026Article
- Exercise and cold exposure as dual physiological stressors in MASLD: AMPK-mediated metabolic adaptation and interorgan crosstalk.Frontiers in physiology · 2026Review
- Combined effects of apparent low temperature and PMFrontiers in public health · 2026Article
- Adaptive restoration of T-cell motility by cold acclimation through metabolic and transcriptional remodeling.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold stress is the therapeutic paradox of cardiovascular medicine: both an established environmental trigger of acute death and a physiological stimulus for powerful adaptation. In this review, we address this paradox critically. The response to cold challenge, which ranges from sympathetic activation and hemodynamic stress to adaptive brown adipose tissue recruitment and cardiac metabolic remodeling, which can be pathological or protective. We synthesize evidence from specific cardiovascular diseases, such as coronary disease and heart failure, and summarize molecular pathways of metabolic, inflammatory, and electrophysiological effects. Native adaptive mechanisms and their therapeutic potential as templates are also discussed. Through synthesis of these multi-faceted avenues, this article builds upon a theoretical basis to propose a mechanistic model for the seasonal regulation of CVD and to outline emerging, cold-based research avenues.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.