Evidence map›Paper›PMID 41574390›Full record

SynthesisInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

Perinatal mortality in eastern Africa: A systematic review and meta-analysis.

Yohanis Alemeshet Asefa, Assefa Tola Gemeda, Hannah Blencowe, Nega Assefa, Lars Åke Persson, Anna C Seale

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Letter to the editor: Perinatal mortality in eastern Africa: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  2. Response: Perinatal mortality in eastern Africa: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yohanis Alemeshet AsefaDepartment of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0003-1209-4289
Assefa Tola GemedaSchool of Public Health, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.
Hannah BlencoweDepartment of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK.
Nega AssefaDepartment of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK.
Lars Åke PerssonDepartment of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.
Anna C SealeDepartment of Infectious Disease Epidemiology and International Health, London School of Hygiene and Tropical Medicine, London, UK.

Funding

Gates Foundation INV-003659
6 · The paper itself

Abstract

backgroundEvery day, over 5000 stillbirths and more than 6000 newborn deaths are estimated to occur worldwide, the majority in sub-Saharan Africa and South Asia. Estimates, however, rely on data that might underestimate these deaths. Further, outside major categories such as preterm birth, infection, and complications at delivery, little is known about the causes of death for newborns and even less for stillbirths.

objectivesThis systematic review and meta-analysis aimed to synthesize evidence on the incidence, causes, and risk factors for perinatal mortality in East Africa to inform public health policy.

methodWe searched major databases: Medline, Web of Science, EMBASE, Global Health, SCOPUS, Cochrane Library, CINAHL, HINARI, African Index Medicus, African Journals Online (AJOL), DHS website, and the World Health Organization African Regional Office (AFRO) Library. The search was conducted without imposing any language restrictions. Studies published 2010-2022 reporting perinatal mortality (incidence/causes/risk factors) in East African countries were included. We included all observational studies (cross-sectional, case-control, prospective cohort, and retrospective studies) and community-based trials. We performed meta-analyses with random effects to estimate pooled perinatal mortality rates for the population and health facility settings. We investigated and reduced heterogeneity where appropriate. We summarized causes of death descriptively and synthesized risk factors narratively.

resultsWe included 99 out of 22 889 studies. The pooled population-based perinatal mortality rate was 33.1/1000 births (95% confidence interval [CI]: 29.3-37.1, I

conclusionPerinatal mortality remains high in East Africa. Many deaths were preventable through addressing modifiable risk factors and strengthening health systems to provide quality antenatal and intrapartum care. Consistent use of standardized cause-of-death classification and improved data quality are needed to enhance the understanding of specific causes of death and target interventions.

Indexed as

Perinatal MortalityAfrica, EasternCause of DeathFemaleHumansIncidenceInfant, NewbornPregnancyRisk FactorsStillbirthearly neonatal mortalityEast Africaperinatal mortalitystillbirthsystematic review

Identifiers

PMID41574390
PMCPMC13173618

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.