Observational studyEuropean journal of neurology2026
Myasthenia Gravis Outcomes After Use of Statins and Other Contraindicated Treatments: Results From the French National Insurance Database.
Observational study in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Statins and Myasthenia Gravis: Clinical Implications and Pathogenesis.International journal of molecular sciences · 2026Review
- Non-Cyclic Rozanolixizumab Administration in Complex Generalized Myasthenia Gravis.Muscle & nerve · 2026Article
- Statin Therapy and Myasthenic Crisis: Is It a Transient Signal or a Clinically Meaningful Risk?Journal of clinical neurology (Seoul, Korea) · 2026Article
- Myasthenia Gravis Outcomes After Use of Statins and Other Contraindicated Treatments: Results From the French National Insurance Database.European journal of neurology · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundClinical guidelines for treating myasthenia gravis (MG) recommend avoiding certain therapies because of a risk of exacerbating MG. We evaluated use of statins and other classically contraindicated therapies and their impact on healthcare outcomes among patients with MG in France.
methodsThis was an observational, retrospective, longitudinal cohort study using data from the French national health insurance database. Adult patients with MG-related claims from 2013 to 2020 were included. The first MG claim date was the index date, with follow-up until end-of-study or death. Multivariable regression models evaluated the risk of intensive care unit (ICU) admission for MG or death during periods of exposure versus nonexposure to contraindicated treatments.
resultsOf 14,459 individuals with MG, 12,954 (89.6%) received a contraindicated treatment during follow-up, and 4160 (28.8%) received statins. In multivariable regression analyses, exposure to any contraindicated treatment was not significantly associated with risk of ICU admission for MG (hazard ratio [HR] 1.038; 95% confidence interval [CI] 0.968-1.113; p = not significant) but was associated with significantly higher risk of death (HR 1.167; 95% CI 1.075-1.266; p < 0.001) versus nonexposure. In contrast, statins were associated with a greater risk of ICU admission (HR 1.133; 95% CI 1.065-1.205; p < 0.001) but lower risk of death (HR 0.626; 95% CI 0.565-0.694; p < 0.001).
conclusionThis large, real-world study suggests that for some contraindicated medications, including statins, longer-term mortality benefits are likely to outweigh short-term risks of exacerbating MG.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.