Evidence map›Paper›PMID 41574704›Full record

ArticleInternational journal of molecular medicine2026

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway.

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cui-Cui Gong *Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Hua-Kang Li *Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Yuan-Zhen MiChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Jun-Yang ChenDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China.
Zeng-Yi FangSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, P.R. China.
Shun-Lian FuChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Li QuanChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Bing LinChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Jin-Yi LangChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Qiu ChenDepartment of Endocrine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, P.R. China.
Ke XuDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China.
Mei-Hua ChenChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation‑induced lung injury (RILI) remains a dose‑limiting and life‑threatening complication of thoracic radiotherapy. The present study aimed to evaluate the therapeutic efficacy and mechanism of the naturally extracted flavonoid, 5,7,8‑trimethoxyflavone (HY‑N7656), in inhibiting RILI. Lung injury in mice was evaluated using micro‑computed tomography, histopathological analysis, enzyme‑linked immunosorbent assay and western blotting. Network pharmacology was conducted to predict the potential therapeutic targets and signaling pathways of HY‑N7656 in RILI. Cell Counting Kit‑8, wound healing, immunofluorescence, reverse transcription‑quantitative (RT‑q) PCR and protein expression analyses were carried out

Indexed as

Epithelial-Mesenchymal TransitionFlavonesFlavonoidsLung InjuryPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRadiation InjuriesSignal TransductionA549 CellsAnimalsHumansMaleMiceMolecular Docking SimulationFlavonesFlavonoidsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt578‑trimethoxyflavoneepithelial‑mesenchymal transitionPI3K/Aktpulmonary fibrosisradiation‑induced lung injury

Identifiers

PMID41574704
PMCPMC12851852

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.