ArticleThe Journal of international medical research2026
Unveiling the mediating role of immune cells in the link between pathogen infections and Hashimoto's thyroiditis.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
BackgroundThis study employed Mendelian randomization to investigate the relationships between pathogenic infections, immunophenotypes, and Hashimoto's thyroiditis, providing deeper insights into infection-induced Hashimoto's thyroiditis development beyond the limitations of small, inconclusive observational studies.MethodsData on pathogenic infections, immune cells, and Hashimoto's thyroiditis were obtained from public databases. The inverse variance weighted method was used as the primary analytical approach, with robustness of the findings confirmed through heterogeneity and pleiotropy tests.ResultsMendelian randomization analysis demonstrated a causal relationship between anti-polyomavirus 2 IgG seropositivity and Hashimoto's thyroiditis (inverse variance weighted: odds ratio = 1.145, 95% confidence interval: 1.069-1.225,
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