Evidence map›Paper›PMID 41575388›Full record

ReviewDiabetes care2026

The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience.

Mark A Espeland, Charles T Semelka, Stephen B Kritchevsky, Joni K Evans, Anne B Newman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark A EspelandDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.ORCID 0000-0002-3711-1949
Charles T SemelkaDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
Stephen B KritchevskyDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
Joni K EvansDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC.
Anne B NewmanSchool of Public Health, University of Pittsburgh, Pittsburgh, PA.

Funding

NIA NIH HHS AG058571NIA NIH HHS AG073697NIA NIH HHS AG074562NIDDK NIH HHS DK125292NIDDK NIH HHS DK57136
6 · The paper itself

Abstract

The 10-year Action for Health in Diabetes (Look AHEAD) clinical trial compared a multidomain intensive lifestyle intervention to a diabetes support and education program with respect to major cardiovascular disease events (primary outcome) and other diabetes- and obesity-related outcomes. Follow-up of the cohort continues to add other aging-related outcomes and conditions to identify the long-term consequences of factors related to lifestyle and medical care. In this transition to a study of aging among individuals at risk for accelerated aging due to type 2 diabetes and overweight or obesity, the investigators have retrospectively reframed the study using the perspective of geroscience. This perspective strengthens the importance of lifestyle changes as a core component for medical care for these individuals to slow biological aging.

Indexed as

Diabetes Mellitus, Type 2AgingCardiovascular DiseasesHumansLife StyleObesityRetrospective Studies

Identifiers

PMID41575388
PMCPMC13294790

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.