Evidence map›Paper›PMID 41575569›Full record

ArticleDie Naturwissenschaften2026

Stigmasterol restores testicular and sperm function in ICR mice exposed to high oxidative stress condition.

Selvakumar Mararajah, Nelli Giribabu, Praveen Kumar Korla, Naguib Salleh

Abstract read
PubMed Publisher
In one paragraph

Article in Die Naturwissenschaften, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Selvakumar MararajahDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.
Nelli GiribabuDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia. nelli.giribabu@um.edu.my.
Praveen Kumar KorlaDepartment of Clinical Science, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Naguib SallehDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia. naguib.salleh@gmail.com.

Funding

UMSC Care Research Fund PV060-2018
6 · The paper itself

Abstract

This study identifies the role of stigmasterol in preserving male fertility via mitigating testicular and sperm destruction in high oxidative stress condition.

methodsOxidative stress was induced in male mice via oral administration of 2% hydrogen peroxide (H

resultsStigmasterol restores testicular morphology, serum testosterone, LH and FSH levels, sperm parameters and Nrf2, SOD, CAT, GPx, Nqo1, HO-1, StAR, ZO-2, and Connexin-43 expression levels while decreases MDA and Keap1 expression levels in mouse testes.Stigmasterol also help to restore sperm motility, viability, its membrane integrity, and Nqo1 antioxidant levels and decreases sperm DNA fragmentation.

conclusionStigmasterol could be used to restore male fertility following exposure to high oxidative stress condition.

Indexed as

Oxidative StressSpermatozoaStigmasterolTestisAnimalsHydrogen PeroxideMaleMiceMice, Inbred ICRSperm MotilityTestosteroneHydrogen PeroxideStigmasterolTestosteroneH2O2-induced oxidative stressSperm functionsStigmasterolTestes

Identifiers

PMID41575569

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.